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Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension. | LitMetric

Generation of two induced pluripotent stem cell lines from patients suffering from pulmonary hypertension.

Stem Cell Res

Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Published: October 2023

AI Article Synopsis

  • Idiopathic pulmonary arterial hypertension (IPAH) is a rare condition affecting 500-1000 individuals yearly, with some cases linked to mutations in the BMPR2 gene, indicating a genetic factor in its onset.
  • Researchers have developed two human induced pluripotent stem cell (iPSC) lines from IPAH patients, which can serve as models to study the disease.
  • These iPSC lines will help researchers gain insights into the biological processes underlying IPAH and could aid in developing new treatments.

Article Abstract

Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease, with an estimated 500-1000 new cases diagnosed every year. A portion of these cases may be caused by mutations in the BMPR2 gene, suggesting a possible genetic component in the development of the disease. Here, we report two human induced pluripotent stem cell (iPSC) lines generated from IPAH patients. Both cell lines provide valuable insight into the molecular and cellular mechanisms of IPAH and can be used to further understand the disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006094PMC
http://dx.doi.org/10.1016/j.scr.2023.103218DOI Listing

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