The clinical utility of Coccidioides species antifungal susceptibility testing (AST) remains unclear. This study describes the clinical course of eight patients with severe or chronic coccidioidomycosis and subsequent Coccidioides AST. We present the clinical manifestations, antifungal treatment regimens, and clinical outcomes for these patients.
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http://dx.doi.org/10.1093/mmy/myad104 | DOI Listing |
Infect Dis Clin North Am
December 2024
Department of Internal Medicine, Division of Infectious Diseases, University of California Davis Medical Center, Sacramento, CA, USA; Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA; UC-Davis Center for Valley Fever. Electronic address:
Coccidioidomycosis is the clinical disease caused by the dimorphic pathogenic fungi Coccidioides immitis and C posadasii. The number of clinically recognized coccidioidomycosis cases continues to increase yearly including in regions outside the traditional regions of endemicity. Following inhalation of Coccidioides spores, the course may range from asymptomatic exposure with resultant immunity, to a subacute pulmonary illness, to life-threatening disseminated infection.
View Article and Find Full Text PDFTranspl Infect Dis
December 2024
Division of Infectious Diseases, Mayo Clinic, Phoenix, Arizona, USA.
mSphere
December 2024
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA.
spp. are part of a group of thermally dimorphic fungal pathogens, which grow as filamentous cells (hyphae) in the soil and transform to a different morphology upon inhalation into the host. The host form, the spherule, is unique and highly undercharacterized due to both technical and biocontainment challenges.
View Article and Find Full Text PDFChest
December 2024
Division of Infectious Diseases, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA; University of Arizona, Tucson, AZ, USA.
Coccidioidomycosis (CM), caused by the dimorphic fungi Coccidioides immitis (C. immitis) and C. posadasii, is recognized as an increasing threat both nationally and worldwide.
View Article and Find Full Text PDFJ Am Vet Med Assoc
December 2024
4Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.
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