AI Article Synopsis
- The study investigates the link between anti-β2-glycoprotein I/HLA-DR antibodies and vascular thromboses in women with systemic rheumatic diseases, particularly in the context of antiphospholipid syndrome (APS).
- A total of 704 patients were analyzed, revealing high antibody levels in those with a history of arterial and venous thromboses, particularly among patients with certain risk profiles.
- The findings suggest that these antibodies are significantly associated with arterial thrombosis, potentially improving risk assessment strategies in affected patients.
Article Abstract
Background: β2-glycoprotein I (β2GPI) complexed with human leukocyte antigen DR (β2GPI/HLA-DR) was found to be a major autoantibody target in antiphospholipid syndrome (APS). This study aimed to reveal the association between anti-β2GPI/HLA-DR antibodies and vascular thromboses in women with systemic rheumatic diseases.
Methods: We conducted a retrospective longitudinal study. We measured anti-β2GPI/HLA-DR antibodies and compared them with anti-phospholipid antibody (aPL) profiles and the adjusted global antiphospholipid syndrome score (aGAPSS). Using receiver operating characteristic (ROC) analysis, we determined the best cut-off value for arterial thrombosis. We also evaluated the validity of anti-β2GPI/HLA-DR antibodies by adding to conventional cardiovascular risk factors in multivariate logistic analysis.
Results: We evaluated 704 patients, including 66 (obstetric or thrombotic) APS, 13 primary APS, and 78 asymptomatic aPL carriers. Seventy-seven patients had a history of arterial thrombosis, and 14 patients had both arterial and venous thrombosis. These 14 patients, as well as patients with aGAPSS > 10 or triple-positive aPL profiles, displayed high anti-β2GPI/HLA-DR antibody titers. The ROC curve showed a sensitivity, specificity, and area under the curve (AUC) for arterial thrombosis of 33.8%, 91.4%, and 0.6009, respectively, with a cut-off value of 172.359 U/mL. The anti-β2GPI/HLA-DR antibody positivity using this cut-off value yielded an odds ratio of 5.13 (95%CI: 2.85-9.24), significantly improving the AUC from 0.677 to 0.730.
Conclusion: Anti-β2GPI/HLA-DR antibodies are associated with arterial thrombosis in female patients with systemic rheumatic diseases.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557208 | PMC |
| http://dx.doi.org/10.1186/s13075-023-03175-8 | DOI Listing |
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