AI Article Synopsis
- Passive immunization with broadly neutralizing antibodies (bNAbs) is being tested as a way to prevent HIV-1 acquisition, particularly important due to the absence of an effective vaccine.
- The study specifically investigates the use of the bNAb 10-1074 delivered in a vaginal microbicide gel, which shows significant efficacy against cell-associated SHIV transmission in non-human primates.
- Results indicate that the treated group had a much lower infection rate, suggesting that this method could be a viable strategy for preventing HIV transmission and warrants further investigation in human clinical trials.
Article Abstract
Passive immunization using broadly neutralizing antibodies (bNAbs) is investigated in clinical settings to inhibit HIV-1 acquisition due to the lack of a preventive vaccine. However, bNAbs efficacy against highly infectious cell-associated virus transmission has been overlooked. HIV-1 transmission mediated by infected cells present in body fluids likely dominates infection and aids the virus in evading antibody-based immunity. Here, we show that the anti-N-glycans/V3 loop HIV-1 bNAb 10-1074 formulated for topical vaginal application in a microbicide gel provides significant protection against repeated cell-associated SHIV vaginal challenge in non-human primates. The treated group has a significantly lower infection rate than the control group, with 5 out of 6 animals fully protected from the acquisition of infection. The findings suggest that mucosal delivery of potent bnAbs may be a promising approach for preventing transmission mediated by infected cells and support the use of anti-HIV-antibody-based strategies as potential microbicides in human clinical trials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558491 | PMC |
| http://dx.doi.org/10.1038/s41467-023-41966-4 | DOI Listing |
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