AI Article Synopsis
- * The study found that while anthraquinone did not cause genetic mutations or chromosomal damage in certain tests, it negatively impacted pregnant rats when administered in high doses, affecting their health and fetal development.
- * The research identified a no observed adverse effect level (NOAEL) of 21.76 mg/kg BW and a lowest observed adverse effect level (LOAEL) of 217.6 mg/kg BW, indicating safe and harmful dosage thresholds for the compound.
Article Abstract
Anthraquinone is a recently identified contaminant present in teas globally, and its potential teratogenic and genotoxic impacts have yet to be fully comprehended. Hence, this study's objective was to determine anthraquinone's genotoxicity using various studies such as the Ames test, Mammalian erythrocyte micronucleus test, and in-vitro mammalian chromosome aberration study. Additionally, the study assessed its effects on maternal gestational toxicity and the fetus's teratogenicity through prenatal developmental toxicity research in rats. Results indicated that anthraquinone did not manifest mutagenic effects on Salmonella typhimurium histidine-deficient, did not cause chromosomal aberrations in Chinese hamster ovary cell subclone CHO-K1, and did not exhibit a genotoxic effect on mouse bone marrow erythrocytes. However, in the prenatal developmental toxicity study, administering anthraquinone orally to pregnant rats from day 5 to day 19 of gestation resulted in decreased body weight and food consumption of pregnant rats, along with a higher number of visceral malformations in the fetuses in the highest dose group (217.6 mg/kg BW). Additionally, two pregnant rats died in this group. The study has established the no observed adverse effect level (NOAEL) as 21.76 mg/kg BW, while the lowest observed adverse effect level (LOAEL) was 217.6 mg/kg BW.
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| http://dx.doi.org/10.1016/j.toxlet.2023.10.002 | DOI Listing |
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