AI Article Synopsis
- Many regenerative organisms retain adult pluripotent stem cells throughout their lives, but the mechanisms behind this maintenance are not well understood.
- Researchers studied the chromatin organization of stem cell genes in planarians, revealing a unique chromatin state that differs from tissue-specific genes and resembles genes consistently expressed.
- They found that while tissue-specific genes have transcription factor binding sites, stem cell genes possess features that reduce nucleosome binding, allowing for easier expression and relying on chromatin remodelers ISWI and SNF2 to maintain pluripotency.
Article Abstract
Many highly regenerative organisms maintain adult pluripotent stem cells throughout their life, but how the long-term maintenance of pluripotency is accomplished is unclear. To decipher the regulatory logic of adult pluripotent stem cells, we analyzed the chromatin organization of stem cell genes in the planarian . We identify a special chromatin state of stem cell genes, which is distinct from that of tissue-specific genes and resembles constitutive genes. Where tissue-specific promoters have detectable transcription factor binding sites, the promoters of stem cell-specific genes instead have sequence features that broadly decrease nucleosome binding affinity. This genic organization makes pluripotency-related gene expression the default state in these cells, which is maintained by the activity of chromatin remodelers ISWI and SNF2 in the stem cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558129 | PMC |
| http://dx.doi.org/10.1126/sciadv.adh4887 | DOI Listing |
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