Background: This study evaluated the maternal, embryotoxic, and teratogenic effects of the aqueous extract of Casearia sylvestris (AECS), a species listed in the Unique Health System of Brazil, and widely used for treating several conditions, such as diarrhea, wounds, pain, and ulcers.
Methods: Pregnant rats were daily treated orally with 0, 175, 350, or 700 mg/kg/body weight of AECS, from gestational day (GD) 6 to 15 (organogenesis period). On GD 20, the pregnant rats were euthanized, and the litters submitted to an assessment of fetal development.
Results: No clinical signs of toxicity were observed in the dams during the treatment. In the embryo-fetal development study, a significant increase in the basal zone height of the placenta was observed in the intermediate dose group. Furthermore, there was a significant increase in the relative anogenital distance measurement of female fetuses in the lowest and intermediate dose groups. Although no visceral abnormalities were observed in the treated-fetuses, skeletal anomalies evidenced by changes in the ossification of the sternum and the presence of supernumerary ribs were found in the intermediate and high dose groups.
Conclusion: In conclusion, the treatment with AECS during organogenesis at this dose level had detrimental effects on the normal development of fetuses.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/bdr2.2257 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Correlation of Total Polyphenol and Flavonoid Content With Antioxidant Activity of Caucasian Bee Honey.
Food Sci Nutr
January 2025
Laboratory Technology Program Artvin Vocational School, Artvin Çoruh University Artvin Türkiye.
Honey is a natural product gathered by honeybees from the pollen and nectar of various plants and flowers. The homeland of the Caucasian honey bee, which draws attention with its honey production and is one of the most productive bee races known in the world, is Northeastern Anatolia in Türkiye. This study aims to determine and correlate the phenolic content and antioxidant activity of 54 honey samples obtained from the most important gene centers of the Caucasian bee in Türkiye.
View Article and Find Full Text PDFCoffee is a popular beverage with significant commercial and social importance. The study aimed to determine the fatty acids profile, volatile compounds, and concentration of major and trace elements (Na, Mg, K, Ca, P, S, Fe, Mn, Cu, Zn, Cr, Ni, Cd, and Pb) in the two most important varieties of coffee, namely arabica and robusta. The leaching percentages of mineral elements and the effect of boiling time on the transfer of elements to aqueous extracts were also determined.
View Article and Find Full Text PDFAntimicrobial Efficacy of L. Extracts for Dental Caries: Green Extraction Techniques and Bioactive Compounds.
Food Sci Nutr
January 2025
Department of Food Science and Technology, Laser and Biophotonics in Biotechnologies Research Center, Isfahan (Khorasgan) Branch Islamic Azad University Semnan Iran.
Dental caries is a highly prevalent chronic condition globally. In recent years, scientists have turned to natural compounds such as plant extracts as an alternative to address concerns related to biofilm-mediated disease transmission, increasing bacterial resistance, and the adverse impacts of antibiotics. Consequently, this study investigated the antimicrobial properties of ethanolic, hydroethanolic, and aqueous extracts of L.
View Article and Find Full Text PDFSelective Crystallization Separation of Uranium(VI) Complexes from Lanthanides.
Inorg Chem
January 2025
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, P. R. China.
The limited availability of uranium (U) resources poses significant challenges to the advancement of nuclear energy. Recycling uranium from spent fuel is critical, but the coexistence of lanthanides (Ln) complicates the extraction process significantly. Here, we present an N/O ligand, ()-'-(pyridin-2-ylmethylene) picolinohydrazide (), designed for the selective recovery of U(VI) over Ln(III/IV) in acidic environments.
View Article and Find Full Text PDFIsolation of the Major Compounds and Determination of Biological Activities in the Underground Parts of D.Don.
Turk J Pharm Sci
January 2025
Near East University Faculty of Pharmacy, Department of Pharmacognosy, Nicosia, Turkish Republic of Northern Cyprus.
Objectives: D.Don, an edible plant, is widely used in folk medicine. This study aimed to investigate the antioxidant and lipase inhibitory activities of the extracts and isolated compounds from the underground parts of (TOU).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!