AI Article Synopsis
- Cancer-associated fibroblasts (CAFs) are important in altering the extracellular matrix and tumor microenvironment, which helps tumors evade the immune system and spread.
- Research using a mouse model of colorectal cancer revealed a specific group of CAFs that influence the immune response in rectal tumors.
- Gaining insights into how CAFs impact tumor immunity could open up new possibilities for targeted therapies aimed at these cells.
Article Abstract
Cancer-associated fibroblasts(CAFs)remodel the extracellular matrix(ECM)and shape the tumor microenvironment (TME), resulting in immune escape and the promotion of tumor metastasis. Using an orthotopic tumor model of colorectal cancers(CRCs)in mice, we demonstrated that the single-cell RNA sequencing of orthotopic rectal tumors identified a subpopulation of CAFs that modulate the immune response. In this review, we report that understanding the role of CAFs in the TME concerning tumor immunity may lead to future avenues for CAF-targeted therapy.
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