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Resolution of Neuropsychiatric Adverse Events After Switching to a Doravirine-Based Regimen in the Open-Label Extensions of the DRIVE-AHEAD and DRIVE-FORWARD Trials.
J Acquir Immune Defic Syndr
January 2025
MSD France, Puteaux, France.
Background: Neuropsychiatric adverse events (NPAEs) are associated with several antiretrovirals. Doravirine (DOR), a non-nucleoside reverse transcriptase inhibitor indicated for HIV-1 treatment, does not interact significantly with known neurotransmitter receptors in vitro. First-line therapy with DOR-based regimens resulted in significantly fewer NPAEs than efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) and similar rates to those of ritonavir-boosted darunavir (DRV/r) with 2 nucleos(t)ide reverse transcriptase inhibitors (NRTIs) through Week 96 of the phase 3 DRIVE-AHEAD and DRIVE-FORWARD studies, respectively.
View Article and Find Full Text PDFArticle Synopsis
- Recurrent infections after sepsis hospitalization are common, and preexisting immune-suppressive conditions (PISCs) like HIV, organ transplants, or cancer may influence the risk of readmission related to infections.
- A study analyzed data from over 649,000 sepsis admissions and found that 29.2% of patients had PISCs, and those with such conditions had a higher rate of infection-related readmissions (26.1%) compared to those without PISCs (20.8%).
- The research indicated that PISCs increased the risk of readmissions by 5.3%, while other chronic diseases like diabetes and chronic kidney disease also contributed to higher risks, highlighting the significant role of existing health conditions
Pneumocystis jirovecii Pneumonia and HIV-Associated Nephropathy in Acute HIV Infection.
Cureus
September 2024
Internal Medicine, Methodist Dallas Medical Center, Dallas, USA.
Article Synopsis
- HIV is a retrovirus that primarily targets the immune system, leading to various opportunistic infections like pneumonia and kidney-related issues, notably HIV-associated nephropathy (HIVAN).
- Advances in antiretroviral therapy allow individuals with HIV to maintain a normal lifespan and avoid progression to AIDS if treated timely.
- A 32-year-old male patient was diagnosed with HIV and pneumonia, subsequently treated and stabilized, highlighting the importance of early recognition and treatment of HIV and its complications.
Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention : A Randomized Trial.
Ann Intern Med
November 2024
Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana (S.K.Grinspoon).
Article Synopsis
- REPRIEVE was a study that looked at how a medication called pitavastatin affects people with HIV and their risk of getting diabetes.
- The study included over 7,700 participants aged 40 to 75 who didn't have diabetes at the start.
- It found that people with more diabetes risk factors had a greater chance of developing diabetes, especially in places like South Asia.
Mucocutaneous relapse during late latent syphilis as initial presentation of HIV infection.
IDCases
August 2024
Infectious and Tropical Diseases Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro, " University of Palermo, Palermo, Italy.
Syphilis is a re-emerging sexually transmitted infection. According to the definition, latent syphilis is characterized by seroreactivity without clinical manifestations. Here, we reported an atypical case of syphilis in a patient with HIV naïve to the antiretroviral treatment characterized by mucocutaneous relapse that occurred in the late latent stage.
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