Objective: To develop and evaluate a supplementary educational program ("IMPACT") centered on enabling participants to consider specifically and articulate explicitly the best path for and potential impact of their research.
Design: Participants (trainees) and faculty mentors were from all areas of biomedical research. The group worked longitudinally in small, rotating groups, through a process of developing a written statement ("Impact Statement"), an overview ("Impact Storyline") and an oral presentation ("Impact Case") of their work.
Results: One hundred and eighty-seven Fellows enrolled in the program. Of the 179 (96%) Fellows who completed the program, 159 (89%) responded to a post-program survey; 94% indicated that IMPACT was a significant learning experience, 89% indicated that they were more able to identify the long-term potential of their research, 95% felt more able to talk about their work to diverse audiences.
Conclusion: This voluntary educational program was appreciated by the participants and led to increased confidence in their ability to drive their science towards a clear impact and communicating that potential to others. This type of program may aid in redirecting some of the efforts and resources of imaging in OA from the large focus on technical developments to more direct biological and clinical questions which might be resolved with current technology.
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http://dx.doi.org/10.1016/j.ostima.2023.100155 | DOI Listing |
Adv Sci (Weinh)
January 2025
College of Physics Science & Technology, School of Life Sciences, Institute of Life Science and Green Development, Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei Province, Hebei University, Baoding, 071002, China.
Hardware system customized toward the demands of graph neural network learning would promote efficiency and strong temporal processing for graph-structured data. However, most amorphous/polycrystalline oxides-based memristors commonly have unstable conductance regulation due to random growth of conductive filaments. And graph neural networks based on robust and epitaxial film memristors can especially improve energy efficiency due to their high endurance and ultra-low power consumption.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
The Key Laboratory of Spine and Spinal Cord Disease of Jiangxi Province, Nanchang, 330006, China.
Chrysoeriol (CHE) is a naturally occurring compound with established anti-inflammatory and anti-tumor effects. This study examines its potential role in regulating osteoclast differentiation and activity, both of which are crucial for bone remodeling. Computational docking revealed high binding affinity between CHE and RANKL, specifically at the Lys-181 residue of RANKL, suggesting potential inhibitory interactions on osteoclastogenesis.
View Article and Find Full Text PDFApoptosis
January 2025
Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Tangerine peel is a traditional Chinese herb and has been widely applied in foods and medicine for its multiple pharmacological effects. Erythropoietin receptor (EPOR), a member of the cytokine receptor family, is widely expressed in multiple tissues in especial kidney and plays protective effects in adverse physiological and pathological conditions. We hypothesized that it might be EPOR agonists existing in Tangerine peel bring such renal benefits.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Sport Injuries and Corrective Exercises, Faculty of Physical Education and Sport Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
Individuals with intellectual disabilities (ID) often exhibit lower levels of physical fitness compared to the general population, including reduced strength, endurance, flexibility, and coordination. Dynamic neuromuscular stabilization (DNS) training can potentially improve the performance of adults with ID caused by weak motor skills due to a lack of desirable nerve growth during childhood and before puberty. Also, DNS training proposed to improve physical fitness in this population, but the effectiveness and durability of DNS training on specific fitness components have not been well-established.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Identifying cell types and brain regions critical for psychiatric disorders and brain traits is essential for targeted neurobiological research. By integrating genomic insights from genome-wide association studies with a comprehensive single-cell transcriptomic atlas of the adult human brain, we prioritized specific neuronal clusters significantly enriched for the SNP-heritabilities for schizophrenia, bipolar disorder, and major depressive disorder along with intelligence, education, and neuroticism. Extrapolation of cell-type results to brain regions reveals the whole-brain impact of schizophrenia genetic risk, with subregions in the hippocampus and amygdala exhibiting the most significant enrichment of SNP-heritability.
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