AI Article Synopsis
- Circular single-stranded DNA viruses, particularly geminiviruses, utilize a multifunctional protein called Rep for various critical processes, including DNA replication, transcription, and evading host defenses.
- Rep interacts with host proteins and other viral components to form a replication complex essential for geminivirus replication.
- Recent research has highlighted the complex structure and evolutionary background of Rep, which includes an embedded sequence for AC4 that aids in virus infection.
Article Abstract
Circular single-stranded DNA viruses of the family encode replication-associated protein (Rep), which is a multifunctional protein involved in virus DNA replication, transcription of virus genes, and suppression of host defense responses. Geminivirus genomes are replicated through the interaction between virus Rep and several host proteins. The Rep also interacts with itself and the virus replication enhancer protein (REn), which is another essential component of the geminivirus replicase complex that interacts with host DNA polymerases α and δ. Recent studies revealed the structural and functional complexities of geminivirus Rep, which is believed to have evolved from plasmids containing a signature domain (HUH) for single-stranded DNA binding with nuclease activity. The Rep coding sequence encompasses the entire coding sequence for AC4, which is intricately embedded within it, and performs several overlapping functions like Rep, supporting virus infection. This review investigated the structural and functional diversity of the geminivirus Rep.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548238 | PMC |
| http://dx.doi.org/10.3389/fmicb.2023.1224221 | DOI Listing |
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