AI Article Synopsis
- A 73-year-old woman developed a quickly worsening, ulcerated growth on her eyelid that showed only slight improvement with infection treatment.
- A biopsy confirmed it was primary cutaneous anaplastic large cell lymphoma (pcALCL), a rare disorder, but no other areas of the body were affected, suggesting a good prognosis.
- Treatment usually involves surgical removal with clear margins; for more advanced cases, intravenous brentuximab vedotin is recommended.
Article Abstract
Herein we present case report of a 73-year-old female who developed a rapidly growing, ulcerated lesion on her left superior eyelid. Despite treatment for suspected infection, symptoms only marginally improved. Physical examination revealed a diffusely ulcerated multinodular tumour with overlying haemorrhagic and serosanguineous exudate. A shave biopsy led to a diagnosis of primary cutaneous anaplastic large cell lymphoma (pcALCL), a rare CD30+ lymphoproliferative disorder. The patient had no extracutaneous involvement on PET-CT and her prognosis is good given the indolent nature of pcALCL. Differential diagnoses included merkel cell carcinoma, periocular sebaceous carcinoma, lymphomatoid papulosis, and extranodal natural killer/T cell lymphoma. Prognosis for pcALCL is generally good. Treatment recommendation for pcALCL is surgical excision with negative margins for localised disease, while intravenous brentuximab vedotin is suggested for widespread, relapsed, and refractory disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549867 | PMC |
| http://dx.doi.org/10.1002/ski2.277 | DOI Listing |
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