The chemical investigation of the methanol extract of the roots of (Oliv.) Gilg. exhibited a new 30-norfriedelane triterpenoid, laphocarpanol (), together with seven known compounds, caloncobalactone (), friedelin (), friedelanol ), asperphernamate (), stigmasterol (), sitosterol () and sitosterol-3---D-glucopyranoside (). The structures of the compounds were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antifungal and antibacterial activities. Compound displayed weak antibacterial effect with MIC value of 62.5 μg/mL against . All the isolates were found to be inactive against the tested fungal strains.

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http://dx.doi.org/10.1080/14786419.2023.2263903DOI Listing

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The chemical investigation of the methanol extract of the roots of (Oliv.) Gilg. exhibited a new 30-norfriedelane triterpenoid, laphocarpanol (), together with seven known compounds, caloncobalactone (), friedelin (), friedelanol ), asperphernamate (), stigmasterol (), sitosterol () and sitosterol-3---D-glucopyranoside ().

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Evid Based Complement Alternat Med

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CAS Key Laboratory of Plant Germplasm Enhancement and Speciality Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China.

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Ethnopharmacological Relevance: Traditional medicines play an important role in the management of chronically painful and debilitating joint conditions, particularly in the rural Africa. However, their potential use as sources of medicines has not been fully exploited. The present study was carried to find the medicinal plants traditionally used to manage chronic joint pains in Machakos and Makueni counties in Kenya.

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