The chemical investigation of the methanol extract of the roots of (Oliv.) Gilg. exhibited a new 30-norfriedelane triterpenoid, laphocarpanol (), together with seven known compounds, caloncobalactone (), friedelin (), friedelanol ), asperphernamate (), stigmasterol (), sitosterol () and sitosterol-3---D-glucopyranoside (). The structures of the compounds were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antifungal and antibacterial activities. Compound displayed weak antibacterial effect with MIC value of 62.5 μg/mL against . All the isolates were found to be inactive against the tested fungal strains.
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http://dx.doi.org/10.1080/14786419.2023.2263903 | DOI Listing |
Nat Prod Res
January 2025
Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon.
The chemical investigation of the methanol extract of the roots of (Oliv.) Gilg. exhibited a new 30-norfriedelane triterpenoid, laphocarpanol (), together with seven known compounds, caloncobalactone (), friedelin (), friedelanol ), asperphernamate (), stigmasterol (), sitosterol () and sitosterol-3---D-glucopyranoside ().
View Article and Find Full Text PDFVet Sci
October 2021
Food Security and Safety Niche Area, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag X2046, Mmabatho 2790, South Africa.
Globally, the use of ethnoveterinary medicine as remedies for animal health among different ethnic groups justify the need for a systematic exploration to enhance their potential. In addition, the increasing popularity and utilisation of woody plants remain common in traditional medicine, which may be attributed to their inherent benefits. The current review was aimed at analysing ethnoveterinary surveys, biological activities, and secondary metabolites/phytochemical profiles of the woody plants of South Africa.
View Article and Find Full Text PDFNat Prod Res
February 2023
Chemistry Laboratory, Department of Chemistry Faculty of Science, University of Douala, Douala, Cameroon.
Phytochemical investigation of the methanolic extract of the trunk bark of (Oliv.) Gilg (Achariaceae) led to the isolation of four new compounds, including three new 30-norfriedelane triterpenes, welwitschiilactones D-F (-), one new friedelane triterpene, welwitschioic acid () as well as ten known compounds: stigmastane-3,6-dione (7), a mixture of -sitosterol and stigmasterol ( and ), a mixture of -sitosterol and stigmasterol glucoside ( and ), (2,3,4,5)--(1,3,4,5-tetrahydroxyndecan-2-yl)tetradecanamide (), 1---glucopyranosyl-(2,3,8)-2-[(2')-2-hydroxylpalmitoylamino]-8-octadecene-1,3-diol (12), 3,21-dihydroxy-27-oxo-30-nor-(D:A)-friedo-olean-20(29))en-27,19α-lactone (), 21hydroxy-3,27-dioxo-30-nor-(D:A)-friedo-olean-20(29)-en-27,19α-lactone () and 2,21-dihydroxy-27-oxo-30-nor-(D:A)-friedo-olean-20(29)-en-27,19-lactone (). The structures of all the isolated compounds were determined by extensive spectroscopic analyses (1D and 2D NMR as well as ESI-MS).
View Article and Find Full Text PDFEvid Based Complement Alternat Med
March 2020
CAS Key Laboratory of Plant Germplasm Enhancement and Speciality Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China.
J Ethnopharmacol
September 2011
Department of Veterinary Anatomy and Physiology, University of Nairobi, Nairobi, Kenya.
Ethnopharmacological Relevance: Traditional medicines play an important role in the management of chronically painful and debilitating joint conditions, particularly in the rural Africa. However, their potential use as sources of medicines has not been fully exploited. The present study was carried to find the medicinal plants traditionally used to manage chronic joint pains in Machakos and Makueni counties in Kenya.
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