Flap procedures are complex surgical tools widely used in reconstructive surgery. Flap ischemia is one of the most dangerous complications, both during the surgical procedure and during the patient's recovery, which can quickly lead to tissue necrosis (flap loss) with serious medical and psychological consequences. Today, bedside clinical assessment remains the gold standard for flap monitoring, but timely detection of flap ischemia is a difficult and challenging task, so auxiliary techniques are needed to support flap monitoring. Here we present a prototype of a new optical diagnostic tool, based on visible light absorption in diffuse reflectance spectroscopy, for non-invasive, continuous, real-time monitoring of flaps. The proposed approach is assessed by monitoring flap ischemic scenarios induced on pig animal models. The results obtained support that the proposed approach has great potential, not only for prompt detection of ischemia (in seconds), but also for clear differentiation between an arterial occlusion and venous occlusion.
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http://dx.doi.org/10.1038/s41598-023-44017-6 | DOI Listing |
Anal Chim Acta
January 2025
MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350116, PR China. Electronic address:
Flap endonuclease 1 (FEN1) plays a vital role in cancer by modulating DNA repair mechanisms, inducing genomic instability, and serving as a promising biomarker for cancer diagnosis and prognosis. In this work, we present the development of a novel DNAzyme signal amplification-directed point-of-care sensing system (Dz-PGM) for the sensitive and specific detection of FEN1. The Dz-PGM system utilizes DNAzyme signal amplification in conjunction with a personal glucose meter (PGM) for reporting, capitalizing on a biochemical cascade initiated by FEN1 recognition.
View Article and Find Full Text PDFJ Clin Med
December 2024
Division of Hand, Plastic and Aesthetic Surgery, University Hospital, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
The perioperative interplay between blood pressure, vasopressors, and macrocirculation is well established. However, in the context of free flap surgery, the potential impact of these factors on microvascular flow remains elusive. The aim was to evaluate the impact of norepinephrine administration on the microcirculation of free flaps.
View Article and Find Full Text PDFCureus
December 2024
Thoracic Surgery, Fukuyama City Hospital, Fukuyama, JPN.
Descending necrotizing mediastinitis (DNM) is a severe, life-threatening infection that requires prompt diagnosis and aggressive surgical intervention. Management is particularly challenging when the condition is complicated by bilateral empyema and perivascular involvement. A 73-year-old woman presented with septic shock several days after experiencing pharyngeal pain.
View Article and Find Full Text PDFHead Neck
January 2025
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA.
Background: The superior thyroid artery (STA) as a recipient vessel in free flap reconstruction may theoretically impact thyroid function. This study aimed to assess whether the use of the STA has an adverse effect on thyroid function.
Methods: Retrospective review of 101 head and neck reconstructive cases.
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