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Development of an American and Australian co-designed youth mental health literacy program.
Front Child Adolesc Psychiatry
June 2023
Michigan State University, East Lansing, MI, United States.
Adolescence is marked by a high prevalence of mental health concerns, with approximately 14% of young individuals receiving a diagnosis of a mental illness disorder. This figure is projected to rise in the future. However, barriers such as limited access to mental health services, a shortage of mental health professionals, and the enduring stigma surrounding mental health prevent many adolescents from seeking help, potentially resulting in long-term negative outcomes.
View Article and Find Full Text PDFVaccination Against Influenza and Pneumococcus During Pretravel Health Consultations in the United States: Interventions and Missed Opportunities.
Open Forum Infect Dis
January 2025
Harvard Medical School, Boston, Massachusetts, USA.
Background: Infections by and influenza viruses are vaccine-preventable diseases causing great morbidity and mortality. We evaluated pneumococcal and influenza vaccination practices during pre-international travel health consultations.
Methods: We evaluated data on pretravel visits over a 10-year period (1 July 2012 through 31 June 2022) from 31 sites in Global TravEpiNet (GTEN), a consortium of US healthcare facilities providing pretravel health consultations.
Optimized circular RNA vaccines for superior cancer immunotherapy.
Theranostics
January 2025
Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Circular RNA (circRNA) has gained attention as a promising platform for mRNA vaccines due to its stability, sustained protein expression, and intrinsic immunostimulatory properties. This study aimed to design and optimize a circRNA cancer vaccine platform by screening for efficient internal ribosome entry sites (IRES) and enhancing circRNA translation efficiency for improved cancer immunotherapy. We screened 29 IRES elements to identify the most efficient one for immune cell translation, ultimately discovering the A (EV-A) IRES.
View Article and Find Full Text PDFThe Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review.
Cancer Manag Res
January 2025
School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People's Republic of China.
Background: Cancer immunotherapy is an advanced therapeutic approach that harnesses the body's immune system to target and eliminate tumor cells. Traditional Chinese medicine (TCM), with a history rooted in centuries of clinical practice, plays a crucial role in enhancing immune responses, alleviating cancer-related symptoms, and reducing the risks of infections and complications in cancer patients.
Methodology: This review systematically examines the current literature on TCM-based formulations in cancer immunotherapy.
"Post-Kasai Portoenterostomy Cholangitis: What Have We Learnt So Far?".
J Clin Exp Hepatol
December 2024
Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
Post-Kasai portoenterostomy (KPE) cholangitis is one of the most common complications that has a negative impact on liver function and native liver survival. Early diagnosis and judicious empiric antimicrobial management are, therefore, important to prevent further liver damage and decompensation. However, there is no consensus regarding the standard definition of post-KPE cholangitis, and established guidelines on evaluation and management are also lacking.
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