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Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review.
Hypertens Pregnancy
December 2024
Department of Obstetrics and Gynecology, Women's Hospital Zhejiang University School of Medicine, Hangzhou, China.
Background: Preeclampsia (PE) is a pregnancy disorder that represents a major cause of maternal and perinatal morbidity and mortality.
Methods: This network meta-analysis was registered with PROSPERO. We searched the PubMed, ClinicalTrials.
Pharmaceutical administration for severe hypertension during pregnancy: Network meta-analysis.
Front Pharmacol
January 2023
Center for Evidence-Based Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
To evaluate the efficacy of different pharmacologic treatment for severe hypertension during pregnancy. Two reviewers searched Ovid MEDLINE, Ovid EMbase, and the Cochrane Library for randomized clinical trials from the establishment of the database to 15 July 2021 that were eligible for inclusion and analyzed the pharmaceuticals used for severe hypertension in pregnancy. 29 relevant trials with 2,521 participants were involved.
View Article and Find Full Text PDFAntihypertensive Medications for Severe Hypertension in Pregnancy: A Systematic Review and Meta-Analysis.
Healthcare (Basel)
February 2022
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung 40132, Indonesia.
Background: Hypertension in pregnancy causes significant maternal and fetal mortality and morbidity. A comprehensive assessment of the effectiveness of antihypertensive drugs for severe hypertension during pregnancy is needed to make informed decisions in clinical practice. This systematic review aimed to assess the efficacy and safety of antihypertensive drugs in severe hypertension during pregnancy.
View Article and Find Full Text PDFHigh-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain.
ACS Chem Biol
January 2022
Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are critical for replication and virus-induced pathogenesis; therefore, these enzymes are a promising target for antiviral therapy. However, no potent or selective viral macrodomain inhibitors currently exist, in part due to the lack of a high-throughput assay for this class of enzymes.
View Article and Find Full Text PDFA double-blind, placebo-controlled trial on the antihypertensive treatment effect of a quadruple single-pill combination.
J Clin Hypertens (Greenwich)
April 2021
Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
In a randomized, double-blind, placebo-controlled trial, we investigated antihypertensive treatment effect of a quadruple single-pill combination of reserpine 0.1 mg, dihydralazine 12.5 mg, hydrochlorothiazide 12.
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