AI Article Synopsis
- * Out of 2,373 studies reviewed, 9 were included, revealing a AAA prevalence of 9% and a 27% incidence rate over 12 months, particularly higher in real-life settings compared to clinical trials.
- * Factors linked to increased AAA generation included not using additional immunosuppressants, having autoimmune diseases, and being female, emphasizing the need for more research on this topic.
Article Abstract
Objective: To review the prevalence, incidence, and risk factors for developing anti-drug antibodies (AAA) in patients with non-infectious uveitis (NIU) treated with Adalimumab (ADA).
Methods: A systematic literature search was performed on PubMed, EMBASE, Virtual Health Library, Cochrane, and medRxiv. Meta-analysis was performed using random effects.
Results: Nine out of 2,373 studies were included. The prevalence of AAA in NIU patients treated with ADA was 9% (95% CI: 2% to 37%, I = 95% with a P<0.01), it was significantly higher in real-life scenarios (observational studies) than in clinical trials. The pooled incidence at 12 months was 27% (CI 95% 16%-42% I = 0%). Several factors have been associated with AAA generation in NIU patients, including the non-use of concomitant immunosuppressants, presence of autoimmune systemic disease, female gender, etc.
Conclusion: This study showed that AAA prevalence is higher in real-life scenarios compared to clinical trials. Further research is needed to elucidate the factors that trigger AAA generation in NIU patients.
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| http://dx.doi.org/10.1080/09273948.2023.2256850 | DOI Listing |
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