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Deep learning classification of MGMT status of glioblastomas using multiparametric MRI with a novel domain knowledge augmented mask fusion approach.
Sci Rep
January 2025
Department of Electrical Electronical Engineering, Yaşar University, Bornova, İzmir, Turkey.
We aimed to build a robust classifier for the MGMT methylation status of glioblastoma in multiparametric MRI. We focused on multi-habitat deep image descriptors as our basic focus. A subset of the BRATS 2021 MGMT methylation dataset containing both MGMT class labels and segmentation masks was used.
View Article and Find Full Text PDFMultilevel Analysis of Ground Beetle Responses to Forest Management: Integrating Species Composition, Morphological Traits and Developmental Instability.
Ecol Evol
January 2025
Department of Zoology, Fisheries, Hydrobiology and Apiculture, Faculty of Agronomy Mendel University in Brno Brno Czech Republic.
This study evaluates the response of ground beetle (Coleoptera: Carabidae) assemblage to forest management practices by integrating species composition, body traits, wing morphology and developmental instability. Traditional approaches that rely on averaged identity-based descriptors often overlook phenotypic plasticity and functional trait variability, potentially masking species-specific responses to environmental changes. To address this, we applied a three-layered analytical approach to address this gap, utilising ground beetle occurrence and morphological trait data from Podyjí National Park, Czech Republic.
View Article and Find Full Text PDFDeep Radiogenomics Sequencing for Breast Tumor Gene-Phenotype Decoding Using Dynamic Contrast Magnetic Resonance Imaging.
Mol Imaging Biol
January 2025
Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211, Geneva, Switzerland.
Purpose: We aim to perform radiogenomic profiling of breast cancer tumors using dynamic contrast magnetic resonance imaging (MRI) for the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) genes.
Methods: The dataset used in the current study consists of imaging data of 922 biopsy-confirmed invasive breast cancer patients with ER, PR, and HER2 gene mutation status. Breast MR images, including a T1-weighted pre-contrast sequence and three post-contrast sequences, were enrolled for analysis.
The Effect of Blood Pressure on Rates of Progression in Focal Ischemic versus Generalized Cup Enlargement Glaucoma Phenotypes.
Ophthalmol Glaucoma
January 2025
Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA. Electronic address:
Purpose: To investigate the impact of blood pressure (BP) on rates of retinal nerve fiber layer (RNFL) thinning in glaucomatous eyes with focal ischemic (FI) versus generalized enlargement (GE) optic disc phenotypes.
Design: Prospective cohort study.
Participants: The study included 122 eyes from 101 patients diagnosed with primary open-angle glaucoma.
High-Frequency Ultrasound for Detecting Periodontal Inflammation: A Preclinical Diagnostic Accuracy Study.
J Periodontal Res
January 2025
Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Aim: Ultrasonography (US) has shown accuracy in imaging healthy periodontium. This study aims to evaluate the feasibility and accuracy of US for estimating dimensions of inflamed periodontium induced by ligature and bacteria.
Methods: Periodontal tissues of maxillary as well as mandibular premolars and molars in six female mini pigs were treated with ligature and three strains of bacteria for 4-10 weeks.
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