AI Article Synopsis
- African swine fever virus (ASFV) leads to a fatal disease in pigs and significantly affects economies in Africa, Europe, and Asia.
- The A179L protein of ASFV inhibits apoptosis in infected cells, allowing the virus to replicate more effectively; without this protein, cell death increases and virus replication decreases.
- Pigs immunized with a virus lacking the A179L gene showed no clinical signs of illness, but still got infected by the deadly virus, indicating the A179L protein is crucial for the virus's ability to replicate and cause disease.
Article Abstract
African swine fever virus (ASFV) causes a lethal disease of pigs with high economic impact in affected countries in Africa, Europe, and Asia. The virus encodes proteins that inhibit host antiviral defenses, including the type I interferon response. Host cells also activate cell death through a process called apoptosis to limit virus replication. We showed that the ASFV A179L protein, a BCL-2 family apoptosis inhibitor, is important in reducing apoptosis in infected cells since deletion of this gene increased cell death and reduced virus replication in cells infected with the A179L gene-deleted virus. Pigs immunized with the BeninΔA179L virus showed no clinical signs and a weak immune response but were not protected from infection with the deadly parental virus. The results show an important role for the A179L protein in virus replication in macrophages and virulence in pigs and suggest manipulation of apoptosis as a possible route to control infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617521 | PMC |
| http://dx.doi.org/10.1128/jvi.01106-23 | DOI Listing |
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