Quinolone-resistant nontyphoidal is a pressing public health concern, demanding the exploration of novel treatments. In this study, we focused on two innovative synthetic fluoroquinolones, WQ-3034 and WQ-3154. Our findings revealed that these new compounds demonstrate potent inhibitory effects, even against mutant strains that cause resistance to existing quinolones. Hence, WQ-3034 and WQ-3154 could potentially be effective therapeutic agents against quinolone-resistant Typhimurium. Furthermore, the data obtained in this study will be baseline information for antimicrobial drug development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715191 | PMC |
| http://dx.doi.org/10.1128/spectrum.01330-23 | DOI Listing |
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