AI Article Synopsis
- - The study aimed to compare mortality rates and hospital stay lengths for patients with bloodstream infections (BSIs) caused by ESBL-producing bacteria versus those caused by non-ESBL bacteria.
- - Results indicated no significant difference in 30-day mortality between the two groups, but a delay in effective antibiotic treatment was noted for the ESBL group, with effective treatment administered within 24 hours to only 55.2% of those patients compared to 86.8% in the non-ESBL group.
- - For urinary tract-related BSIs, the ESBL group had a longer average hospital stay, increasing by two days, whereas no significant difference was found for BSIs from other sources.
Article Abstract
Objective: To compare mortality and length of hospital stay between patients with ESBL-producing bloodstream infections (BSIs) and patients with non-ESBL BSIs. We also aimed at describing risk factors for ESBL-producing BSIs and time to effective antibiotic treatment for the two groups.
Methods: A retrospective case-control study among adults admitted between 2014 and 2021 to a Norwegian University Hospital.
Results: A total of 468 BSI episodes from 441 patients were included (234 BSIs each in the ESBL- and non-ESBL group). Among the ESBL-producing BSIs, 10.9% (25/230) deaths occurred within 30 days compared to 9.0% (21/234) in the non-ESBL group. The adjusted 30-day mortality OR was 1.6 (95% CI 0.7-3.7, = 0.248). Effective antibiotic treatment was administered within 24 hours to 55.2% (129/234) in the ESBL-group compared to 86.8% (203/234) in the non-ESBL group. Among BSIs of urinary tract origin ( = 317), the median length of hospital stay increased by two days in the ESBL group (six versus four days, < 0.001). No significant difference in the length of hospital stay was found for other sources of infection ( = 151), with a median of seven versus six days ( = 0.550) in the ESBL- and non-ESBL groups, respectively.
Conclusion: There was no statistically significant difference in 30-day mortality in ESBL-producing compared to non-ESBL BSI, despite a delay in the administration of an effective antibiotic in the former group. ESBL-production was associated with an increased length of stay in BSIs of urinary tract origin.
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| http://dx.doi.org/10.1080/23744235.2023.2261538 | DOI Listing |
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