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| http://dx.doi.org/10.1002/ctm2.1428 | DOI Listing |
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Type I spinal muscular atrophy and disease modifying treatments: a nationwide study in children born since 2016.
EClinicalMedicine
December 2024
Pediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Background: The advent of disease-modifying treatments (DMT) has changed natural history in 5q Spinal muscular atrophy (SMA). The aim of this study was to report survival and functional aspects in all the Italian type I children born since 2016.
Methods: The study included all symptomatic children with type I SMA born since January 1st, 2016, when DMTs became available in Italy.
Prevalence of Duchenne muscular dystrophy in Italy: a nationwide survey.
Eur J Pediatr
December 2024
Pediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Purpose: The availability of care recommendations has improved survival and delayed the progression of clinical signs in Duchenne muscular dystrophy. The aim of the study was to perform a nationwide survey investigating the prevalence, age distribution, and functional status of Duchenne muscular dystrophyin Italy.
Methods: The survey was performed by collecting data from all 31 reference centers for Duchenne muscular dystrophy in Italy using a structured form.
Sustainable Adsorbent: Activated Carbon From Waste Styrofoam for Efficient Aluminum Removal.
Microsc Res Tech
December 2024
Department of Environmental Sciences, Shaheed Benazir Bhutto University, Dir Upper, Khyber Pakhtunkhwa, Pakistan.
This paper reports on batch investigations utilizing activated carbon (AC) made from waste Styrofoam to adsorb aluminum (Al) from aqueous solutions. The AC morphology and structure were examined using Fourier-transform infrared spectroscopy, scanning electron microscopy, and surface area analysis. The factors affecting the performance of adsorption were thoroughly examined.
View Article and Find Full Text PDFGenetic association between inflammatory factors and abdominal aortic aneurysm: Insights from a genome-wide association study.
Int J Cardiol
December 2024
Department of Hematology, Shaoxing People's Hospital, Shaoxing City, Zhejiang Province, PR China. Electronic address:
Article Synopsis
- Abdominal aortic aneurysm (AAA) is a serious vascular condition that currently only has surgical treatment options for advanced stages, with inflammation playing a key role in its development.* -
- A genetic study used Mendelian randomization to analyze the relationship between various inflammatory factors and AAA, identifying specific factors that could either increase or decrease the risk of developing the condition.* -
- The findings suggest that targeting certain inflammatory factors could offer new strategies for preventing and treating AAA without surgical intervention.*
Linear ubiquitination mediates coronavirus NSP14-induced NF-κB activation.
Cell Commun Signal
November 2024
Department of Microbiology and Immunology, Tulane University, New Orleans, LA, 70112, USA.
Human coronaviruses exhibit a spectrum of symptoms, ranging from mild seasonal colds to severe respiratory manifestations. Despite progress in understanding the host's innate defense mechanisms against coronaviruses, how these viruses manipulate the immune response to promote inflammation remains elusive. In this study, we unveil the role of the coronavirus nonstructural protein 14 (NSP14) in leveraging the host's linear ubiquitin chain assembly complex (LUBAC) to instigate NF-κB activation, thereby triggering proinflammatory responses.
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