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http://dx.doi.org/10.1038/s41380-023-02270-1 | DOI Listing |
Mol Psychiatry
January 2025
APC Microbiome Ireland, University College Cork, Cork, Ireland.
Mol Psychiatry
September 2023
International Prevention Research Institute, 95 Cours Lafayette, 69006, Lyon, France.
Transl Psychiatry
March 2023
Department of Psychiatry & Neurobehavioral Science, University College Cork, Cork, Ireland.
The microbiome-gut-brain axis plays a role in anxiety, the stress response and social development, and is of growing interest in neuropsychiatric conditions. The gut microbiota shows compositional alterations in a variety of psychiatric disorders including depression, generalised anxiety disorder (GAD), autism spectrum disorder (ASD) and schizophrenia but studies investigating the gut microbiome in social anxiety disorder (SAD) are very limited. Using whole-genome shotgun analysis of 49 faecal samples (31 cases and 18 sex- and age-matched controls), we analysed compositional and functional differences in the gut microbiome of patients with SAD in comparison to healthy controls.
View Article and Find Full Text PDFEBioMedicine
March 2023
APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. Electronic address:
Background: Binge drinking is the consumption of an excessive amount of alcohol in a short period of time. This pattern of consumption is highly prevalent during the crucial developmental period of adolescence. Recently, the severity of alcohol use disorders (AUDs) has been linked with microbiome alterations suggesting a role for the gut microbiome in its development.
View Article and Find Full Text PDFMol Psychiatry
February 2023
APC Microbiome Ireland, Cork, Ireland.
The impact of diet on the microbiota composition and the role of diet in supporting optimal mental health have received much attention in the last decade. However, whether whole dietary approaches can exert psychobiotic effects is largely understudied. Thus, we investigated the influence of a psychobiotic diet (high in prebiotic and fermented foods) on the microbial profile and function as well as on mental health outcomes in a healthy human population.
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