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Interaction of the Gut-Liver-Brain Axis and the sterolbiome with sexual dysfunction in patients with cirrhosis.
Gut Microbes
December 2025
Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
There is a complex interplay between the gut microbes, liver, and central nervous system, a gut-liver-brain axis, where the brain impacts intestinal and hepatic function while the gut and liver can impact cognition and mental status. Dysregulation of this axis can be seen in numerous diseases. Hepatic encephalopathy, a consequence of cirrhosis, is perhaps the best studied perturbation of this system.
View Article and Find Full Text PDFGlucagon-like peptide1 receptor agonist treatment of cystic fibrosis-related diabetes complicated by obesity: A cases series and literature review.
J Clin Transl Endocrinol
December 2024
Division of Endocrinology Diabetes and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Cystic fibrosis-related diabetes (CFRD) is the most common non-pulmonary comorbidity in people with cystic fibrosis (CF). Current guidelines recommend insulin therapy as the treatment of choice for people with CFRD. In the past, obesity and overweight were uncommon in individuals with CF.
View Article and Find Full Text PDFPrediabetes and diabetes mellitus type II after ischemic stroke.
Eur Stroke J
January 2025
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Introduction: The progression of diabetes status in post-stroke patients remains under-investigated, particularly regarding new treatments for type II diabetes mellitus (DM II), like glucagon-like peptide 1 receptor agonists (GLP-1-RA) and sodium-glucose co-transporter-2 (SGLT-2) inhibitors, which have not been studied in the post-stroke setting.
Patients And Methods: Eight hundred eighty-four consecutive ischemic stroke patients recruited to our prospective STROKE-CARD Registry were assessed concerning their glycemic status at baseline (normoglycemia, prediabetes, DM II) and change over time within 1 year follow-up. Multivariate logistic regression was performed to identify factors associated with transitioning from normoglycemia to prediabetes or DM II.
Determinants of body composition among peri-menopausal women of Bilaspur district, Chhattisgarh, India.
BMC Public Health
January 2025
Department of Anthropology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, M.P, India.
A cross-sectional study was conducted among the peri-menopausal women to find out determinants of body composition. A total of 200 peri-menopusal women were recruited (≥ 40 years) from rural and urban areas of the district Bilaspur (CG). Among the studied respondents the mean age for peri-menopausal women was 42.
View Article and Find Full Text PDFAssociations between the conicity index and kidney stone disease prevalence and mortality in American adults.
Sci Rep
January 2025
Department of Urology, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun City, Jilin Province, China.
Kidney Stone Disease (KSD) is a prevalent urological condition, while abdominal obesity is on the rise globally. The conicity index, measuring body fat distribution, is crucial but under-researched in its relation to KSD and all-cause mortality. This study, using data from 59,842 participants in the NHANES (2007-2018), calculated the conicity index from waist circumference, height, and weight.
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