Introduction: To investigate the relationship between hydrogen sulfide(HS) and the senescence level of the fetal membranes, and to elucidate how HS affects the integrity of the fetal membranes.
Methods: The HS and the senescence levels of fetal membranes, and the expressions of HS synthase CBS and CSE were detected in the preterm (PT) group and the preterm premature ruptured membranes (pPROM) group. The effects of HS donors and knockdown of CBS on the senescence level of amniotic epithelial cells, and the expression level of matrix metalloproteinases (MMPs) and epithelial-mesenchymal translation (EMT) were observed.
Results: The level of HS in the fetal membranes in the pPROM group is significantly lower than that in the PT group matched for gestational age. The level of HS is negatively correlated with the senescence level of fetal membranes. Treatment with HS donors reduced cell senescence and MMPs expression, but did not affect EMT. CBS siRNA transfection accelerated the senescence of amniotic epithelial cells, and promoted the expression of MMPs and EMT occurrence, but l-cysteine could reverse these effects.
Discussion: Our study suggests that HS, through its anti-aging effect, can influence the expression of MMPs and EMT, thereby contributing to the maintenance of fetal membrane integrity.
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