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A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides.
Elife
October 2024
Mycobacteria Research Laboratories, Colorado State University, Fort Collins, United States.
Article Synopsis
- The Nix-TB clinical trial tested a new 6-month TB treatment called the BPaL regimen, which includes bedaquiline, pretomanid, and linezolid, achieving a 90% cure rate in drug-resistant TB patients, but caused severe side effects due to linezolid.
- Researchers propose substituting linezolid with inhaled spectinamide 1599 to create the BPaS regimen, which shows similar effectiveness as the BPaL regimen while reducing adverse events.
- In animal studies, the BPaS regimen demonstrated equivalent bactericidal effects with fewer side effects like weight loss and anemia compared to BPaL, suggesting inhaled spectinamide has a superior safety profile in
Intranasal Administration of Bedaquiline-Loaded Fucosylated Liposomes Provides Anti-Tubercular Activity while Reducing the Potential for Systemic Side Effects.
ACS Infect Dis
September 2024
Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2 ,Vienna 1090, Austria.
Liposomal formulations of antibiotics for inhalation offer the potential for the delivery of high drug doses, controlled drug release kinetics in the lung, and an excellent safety profile. In this study, we evaluated the performance of a liposomal formulation for the poorly soluble, antituberculosis agent, bedaquiline. Bedaquiline was encapsulated within monodisperse liposomes of ∼70 nm at a relatively high drug concentration (∼3.
View Article and Find Full Text PDFHost and pathogen genetic diversity shape vaccine-mediated protection to .
Front Immunol
July 2024
Seattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States.
To investigate how host and pathogen diversity govern immunity against (Mtb), we performed a large-scale screen of vaccine-mediated protection against aerosol Mtb infection using three inbred mouse strains [C57BL/6 (B6), C3HeB/FeJ (C3H), Balb/c x 129/SvJ (C129F1)] and three Mtb strains (H37Rv, CDC1551, SA161) representing two lineages and distinct virulence properties. We compared three protective modalities, all of which involve inoculation with live mycobacteria: Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, delivered either subcutaneously or intravenously, and concomitant Mtb infection (CoMtb), a model of pre-existing immunity in which a low-level Mtb infection is established in the cervical lymph node following intradermal inoculation. We examined lung bacterial burdens at early (Day 28) and late (Day 98) time points after aerosol Mtb challenge and histopathology at Day 98.
View Article and Find Full Text PDFBackground: Tick bites often promote local allergic reactions in the skin and predispose to red meat allergy. The mechanisms involved in these processes are not fully understood. Here we investigated the local changes to the skin and intestine induced by tick bites.
View Article and Find Full Text PDFTreatment of mice with maternal intermittent fasting to improve the fertilization rate and reproduction.
Zygote
June 2024
Department of Reproductive Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan250001, Shandong, China.
Maternal intermittent fasting (MIF) can have significant effects on several tissue and organ systems of the body, but there is a lack of research on the effects on the reproductive system. So, the aim of our study was to analyze the effects of MIF on fertility. B6C3F1Crl (C57BL/6N × C3H/HeN) male and female mice were selected for the first part of the experiments and were analyzed for body weight and fat weight after administration of the MIF intervention, followed by analysis of sperm counts and activation and embryo numbers.
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