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Biphasic Effect of Thyroid Hormone on Megakaryopoiesis and Platelet Production.
Thyroid
December 2024
State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China.
Abnormal platelet counts are frequently observed in patients with thyroid dysfunction; however, the direct impact of thyroid hormones on thrombopoiesis remains largely undefined. This study elucidates the dose-response effect of the thyroid hormone triiodothyronine (T) on megakaryocyte (MK) development and thrombopoiesis using both a murine model of hyperthyroidism/hypothyroidism and cultures of human cord blood CD34 cell-derived MKs. After the application of inhibitors to MKs, the examination of total and phosphorylated protein levels of the phosphoinositide 3-kinase (PI3K)/AKT pathway was utilized to assess the specific mechanisms of T action.
View Article and Find Full Text PDFAssociations between subclinical thyroid dysfunction and cardiovascular risk factors according to age and sex.
J Clin Endocrinol Metab
December 2024
Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Context: Subclinical thyroid dysfunction (ScTD) comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper) has been associated with increased risk for cardiovascular events.
Objective: To assess associations between ScTD and cardiovascular risk factors (cvRFs) according to age and sex.
Design And Setting: Pooled individual participant data analysis of large prospective cohort studies from the Thyroid Studies Collaboration.
Transnasal endoscopic orbital inner wall decompression combined with penetrating keratoplasty for corneal ulcer perforation in Graves' ophthalmopathy: A case report.
Medicine (Baltimore)
October 2024
Department of Orbital Surgery, Chongqing Aier Eye Hospital, Chongqing, China.
Rationale: To report a unique case of corneal ulcer perforation associated with a severe manifestation of Graves' ophthalmopathy that was treated with unilateral transnasal endoscopic orbital inner wall decompression combined with penetrating keratoplasty.
Patient Concerns: A 66-year-old male with Graves' disease experiencing unilateral corneal ulcer perforation, a rarity in medical literature. He presented with a 9-month history of bilateral exophthalmos accompanied by decreased vision, and over the past month, he experienced loss of vision and painful swelling in the right eye (RE).
Utility of ultra-portable ultrasound devices for the risk-stratification of thyroid dysfunctions in an emergency setting.
J Endocrinol Invest
October 2024
Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Article Synopsis
- The study examines the effectiveness of rapid TSH screening in detecting thyroid diseases in patients in the Emergency Department (ED), noting a 7% prevalence of previously undiagnosed thyroid dysfunctions.
- The diagnostic process was enhanced by using a mobile ultrasound device, rPOCUS, to evaluate patients with suppressed rTSH in urgent care situations requiring iodinated contrast.
- Results indicate that rPOCUS is both cost- and time-effective, aiding in the management of hyperthyroidism, reducing unnecessary rTSH tests, and identifying incidental findings that necessitate further evaluation.
Combined Levothyroxine and Propylthiouracil Treatment in Children with Monocarboxylate Transporter 8 Deficiency: A Multicenter Case Series of 12 Patients.
Thyroid
November 2024
Department of Medicine, The University of Chicago, Chicago, Illinois, USA.
To evaluate the combined administration of propylthiouracil (PTU) and levothyroxine (LT4) in managing monocarboxylate transporter 8 (MCT8) deficiency and identify optimal therapeutic dosages. This multicenter case series involved 12 male patients with MCT8 deficiency whose parents/guardians consented to PTU and LT4 treatment. Data were collected from January 2008 to June 24, 2024.
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