AI Article Synopsis
- Polystyrene nanoplastics (PS-NPs) have been detected in human blood and kidneys, but their effects on renal health have not been fully understood.
- Research showed that PS-NPs can lead to cell death (apoptosis) in human kidney cells, influenced by the size and concentration of the particles.
- The study identified that PS-NPs increase reactive oxygen species (ROS) production and alter cell structures, with the MAPK signaling pathway playing a crucial role in the apoptosis process.
Article Abstract
Polystyrene nanoplastics (PS-NPs) have recently been found to be present in human blood and kidney. However, the renal toxicity of PS-NPs and the underlying mechanisms have not been fully elucidated. Here, we found that exposure of PS-NPs induced apoptosis of human renal proximal tubular epithelial cells (HK-2) in a size- and dose-dependent manner as revealed by AnnexinV-FITC assay. In addition, PS-NPs promoted ROS production and caused structure changes of mitochondrial and endoplasmic reticulum. Mechanistically, transcriptional sequencing indicated the involvement of MAPK pathway in apoptosis, which was further confirmed by the upregulation of p-p38, p-ERK, CHOP, BAX, cytochrome C, and caspase 3 expression. This study clarified the molecular mechanism underlying PS-NP-induced apoptosis in HK-2 cells and contributed to our risk estimation of PS-NPs in human kidney.
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| http://dx.doi.org/10.1007/s11356-023-30155-x | DOI Listing |
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