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Adjunctive nivolumab in combination with antibiotic therapy for the management of refractory melioidosis in a patient with metastatic breast cancer and chemotherapy-induced pancytopenia.
Trans R Soc Trop Med Hyg
January 2025
Department of Infectious Diseases, Kasturba Medical College Manipal, Manipal Academy of higher Education, Manipal, Karnataka, India, 576104.
Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to multiple classes of antibiotics and primarily affects immunocompromised individuals, such as those with poorly controlled diabetes or malignancies. In this case, a 58-y-old female farmer with poorly controlled diabetes (HbA1c of 11.4%), metastatic breast cancer with chemotherapy-induced pancytopenia and disseminated melioidosis showed no improvement despite receiving antibiotics and supportive care.
View Article and Find Full Text PDFIntraoperative Cardiovascular Emergency in Spinal Melioidosis Presenting as a Case of Spinal Epidural Abscess: A Rare Case Study of 2 Patients.
Indian J Microbiol
December 2024
Spine Surgery, Apollo Multispecialty Hospital, Kolkata, India.
Melioidosis rarely presents with spinal involvement, which may lead to neurological complications. It's endemic to Thailand and Australia, but rare in India. Patients with diabetes, immunocompromised states, and chronic renal failure are at high risk of developing melioidosis, which can present with localized or disseminated abscess collection.
View Article and Find Full Text PDFGut Microbiome in Human Melioidosis: Composition and Resistome Dynamics from Diagnosis to Discovery.
Open Forum Infect Dis
November 2024
Department of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Background: Melioidosis, attributable to the soil-dwelling bacterium , stands as a paramount global health challenge, necessitating extended courses of antibiotics. While murine studies identified the gut microbiota as a modulator of bacterial dissemination during melioidosis, the human intestinal microbiota during melioidosis remains uncharacterized. Here, we characterized gut microbiota composition and antimicrobial resistance (AMR) genes at diagnosis, during treatment, and postdischarge for melioidosis.
View Article and Find Full Text PDFImaging and clinical manifestations of hematogenous dissemination in melioidosis.
BMC Med Imaging
November 2024
Department of Radiology, The First Affiliated Hospital of Hainan Medical University, 31 Longhua Rd, Haikou, Hainan, China.
Background: Although there is a high incidence of hematogenous infections in melioidosis, a tropical infectious disease, there are few systematic analyses of hematogenous melioidosis in imaging articles. A comprehensive clinical and imaging evaluation of hematogenous melioidosis be conducted in order to achieve early diagnosis of the disease.
Materials And Methods: We conducted an analysis of 111 cases of melioidosis diagnosed by bacteriological culture between August 2001 and September 2022.
Disseminated Melioidosis Complicated by Prostatic Abscess and Splenic Involvement: Diagnostic and Therapeutic Insights.
Cureus
September 2024
Internal Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
This case report details the clinical course of a 53-year-old male farmer with a 15-year history of diabetes mellitus who presented with a 20-day history of pyrexia, rigors, and shivering, as well as problems in the urogenital system and left hypochondrial pain. Notably, he had been diagnosed with spinal tuberculosis, which was successfully treated five years ago. On evaluation, there was tenderness in the suprapubic region as well as the left hypochondrium; moreover, rectal examination showed that the prostate was boggy and tender.
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