Two undescribed frenolicins H and I ( and ) along with six previously described frenolicin analogues [frenolicins A (), B (), UCF76-B (), E - G ( - )] and two anthraquinones [3,8-dihydroxy-1-propylanthraquinone-2-carboxylic acid () and 3,8-dihydroxy-1-propylanthraquinone ()] were isolated from a longkong bark eating caterpillar-derived sp. TBRC17107. The chemical structures were determined by NMR spectroscopic information and HRESIMS data. Frenolicins H () and I () showed weak cytotoxicity against malignant and non-malignant cells. Frenolicins A () and B () showed antimalarial activity against (IC 17.4 and 1.37 M), antibacterial activity against and (MIC 50.0 and 0.20 g/mL). Only frenolicin B had anti-plant pathogenic fungal activity against and with MIC values of MIC 1.56 and 6.25 g/mL, respectively. Frenolicins A and G possessed anti- with equal MICs of 25.0 g/mL.
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