AI Article Synopsis
- Circulating cell-free DNA (cf-DNA) is released during cell death and inflammation and has been linked to kidney function and allograft rejection.
- Previous studies suggest that changes in cf-DNA levels can serve as a noninvasive biomarker for worsening kidney function and may help manage chronic kidney disease (CKD) risks, especially in patients with diabetes and heart conditions.
- Elevated serum cf-DNA levels before and after hemodialysis are associated with higher all-cause mortality in end-stage kidney disease patients.
Article Abstract
Circulating cell-free DNA (cf-DNA) is released from dead and/or apoptotic leukocytes and due to neutrophil extracellular traps contributing to an inflammatory response. Previous clinical studies have reported that the peak concentrations and dynamic changes of cf-DNA may be used as a noninvasive biomarker of worsening kidney function as well as a guide to the management of kidney allograft rejection. We hypothesized that the pattern and dynamic changes of cf-DNA might be a plausible predictive biomarker for patients at risk of chronic kidney disease (CKD), including individuals with type 2 diabetes mellitus, heart failure, cardiovascular disease and established CKD. Along with it, pre- and posthemodialysis levels of serum cf-DNA appear to be a independent predictor for all-cause mortality in patients with end-stage kidney disease.
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| http://dx.doi.org/10.2217/epi-2023-0255 | DOI Listing |
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