Helicene-derived 2,2'-bipyridine -monoxide was evaluated as a Lewis base catalyst for the enantioselective propargylation of -acylhydrazones with allenyltrichlorosilane. The helicene-derived catalyst provided moderate-to-good reactivity and enantioselectivity for a range of acylhydrazones. This study represents the first example of the catalytic asymmetric propargylation of non-activated acylhydrazones.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545348 | PMC |
| http://dx.doi.org/10.1016/j.tet.2023.133496 | DOI Listing |
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