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Combining Treg Therapy With Donor Bone Marrow Transplantation: Experimental Progress and Clinical Perspective. | LitMetric

Combining Treg Therapy With Donor Bone Marrow Transplantation: Experimental Progress and Clinical Perspective.

Transplantation

Division of Transplantation, Department of General Surgery, Medical University of Vienna, Vienna, Austria.

Published: May 2024

AI Article Synopsis

Article Abstract

Donor-specific tolerance remains a goal in transplantation because it could improve graft survival and reduce morbidity. Cotransplantation of donor hematopoietic cells to achieve chimerism is a promising approach for tolerance induction, which was successfully tested in clinical trials. However, current protocols are associated with side effects related to the myelosuppressive recipient conditioning, which makes it difficult to introduce them as standard therapy. More recently, adoptive cell therapy with polyclonal or donor-specific regulatory T cells (Treg) proved safe and feasible in several transplant trials, but it is unclear whether it can induce tolerance on its own. The combination of both approaches-Treg therapy and hematopoietic cell transplantation-leads to chimerism and tolerance without myelosuppressive treatment in murine models. Treg therapy promotes engraftment of allogeneic hematopoietic cells, reducing conditioning requirements and enhancing regulatory mechanisms maintaining tolerance. This review discusses possible modes of action of transferred Treg in experimental chimerism models and describes translational efforts investigating the potent synergy of Treg and chimerism.

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000004814DOI Listing

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