Secondary Analysis of Agreement Between Negative Timeline Follow Back Report and Negative Urine Toxicology in a Large Trial of Individuals with Opioid Use Disorder.

J Addict Med

From the New York State Psychiatric Institute, New York City, NY (MS, T-HC, JS, ANCC, MG, EVN); Department of Psychiatry, Columbia University Medical Center, New York, NY (MS, ANCC, MG, EVN); Department of Biostatistics, Mailman School of Public Health, Columbia University, New York City, NY (MP); Department of Psychiatry, New York University School of Medicine, New York City, NY (JR); and Department of Population Health, New York University, New York City, NY (PN, JDL).

Published: November 2023

Objectives: Timeline follow-back (TLFB) is a self-report measure commonly used as a method of assessing historical drug use in both clinical and research settings. Our study considered rates of agreement between TLFB and an objective biological assay of opioid use.

Methods: We calculated the rates of agreement between negative report of opioid use for the most recent 8 days on TLFB and urine toxicology (UTOX) results in a large multisite opioid use disorder treatment trial.

Results: In total, 3986 assessments were provided by trial participants with both UTOX and TLFB during weeks 1 to 12, 2716 during weeks 13 to 24, and 325 at week 28. Rates of disagreement between negative TLFB and positive opioid UTOX were 2.33% of all assessments (21.68% of those with positive UTOX) over weeks 1 to 12, 2.06% of all assessment (25.00% of those with positive UTOX) over weeks 13 to 24, and 9.85% of all assessments (26.02% of those with positive UTOX) at week 28.

Conclusions: Negative TLFB seems to be generally associated with negative results on urine toxicology.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593984PMC
http://dx.doi.org/10.1097/ADM.0000000000001173DOI Listing

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