AI Article Synopsis
- Radiotherapy (RT) is commonly used to treat various cancers, but it can cause radiation-induced gastric injury (RIGI), leading to issues like gastritis or ulcers.*
- RIGI can present acutely or chronically, and recent research identifies key intracellular signals like oxidative stress and specific signaling pathways that contribute to its progression.*
- The review addresses risk factors, diagnosis, and treatments for RIGI, while emphasizing the need for deeper understanding of its mechanisms to improve therapeutic strategies.*
Article Abstract
Radiotherapy (RT) has been the standard of care for treating a multitude of cancer types. Radiation-induced gastric injury (RIGI) is a common complication of RT for thoracic and abdominal tumors. It manifests acutely as radiation gastritis or gastric ulcers, and chronically as chronic atrophic gastritis or intestinal metaplasia. In recent years, studies have shown that intracellular signals such as oxidative stress response, p38/MAPK pathway and transforming growth factor-β signaling pathway are involved in the progression of RIGI. This review also summarized the risk factors, diagnosis and treatment of this disease. However, the root of therapeutic challenges lies in the incomplete understanding of the mechanisms. Here, we also highlight the potential mechanistic, diagnostic and therapeutic directions of RIGI.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665304 | PMC |
| http://dx.doi.org/10.1093/jrr/rrad071 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metal-organic-framework-based sitagliptin-release platform for multieffective radiation-induced intestinal injury targeting therapy and intestinal flora protective capabilities.
J Nanobiotechnology
October 2024
Department of Oncology, General Hospital of Western Theater Command, Chengdu, 610083, China.
In patients with abdominal or pelvic tumors, radiotherapy can result in radiation-induced intestinal injury (RIII), a potentially severe complication for which there are few effective therapeutic options. Sitagliptin (SI) is an oral hypoglycemic drug that exhibits antiapoptotic, antioxidant, and anti-inflammatory activity, but how it influences RIII-associated outcomes has yet to be established. In this study, a pH-responsive metal-organic framework-based nanoparticle platform was developed for the delivery of SI (SI@ZIF-8@MS NP).
View Article and Find Full Text PDFRadiation-induced liver disease mimicking liver metastasis after low-dose hepatic irradiation during radiotherapy for gastric mucosa-assisted lymphoid tissue lymphoma: A case report.
Medicine (Baltimore)
August 2024
Department of Radiation Oncology, Jeonbuk National University Hospital-Jeonbuk National University Medical School, Jeonju, Jeonbuk, Republic of Korea.
Article Synopsis
- Radiation-induced liver disease (RILD) can occur not only from high-dose liver irradiation but also from unintentional low-dose exposure during treatment for other cancers, highlighting the need for caution.
- A case study of a 44-year-old woman with lymphoma revealed a lesion in her liver one month after undergoing radiotherapy, initially raising concerns about potential metastasis.
- Diagnosis confirmed RILD through biopsy, and after conservative management and monitoring, the patient's liver function and imaging normalized within about three months, showcasing how RILD should be considered when new liver lesions appear post-radiotherapy.
Microbiome in radiotherapy: an emerging approach to enhance treatment efficacy and reduce tissue injury.
Mol Med
July 2024
School of Chemical Engineering, Northwest Minzu University, No.1, Northwest New Village, Lanzhou, Gansu, 730030, China.
Radiotherapy is a widely used cancer treatment that utilizes powerful radiation to destroy cancer cells and shrink tumors. While radiation can be beneficial, it can also harm the healthy tissues surrounding the tumor. Recent research indicates that the microbiota, the collection of microorganisms in our body, may play a role in influencing the effectiveness and side effects of radiation therapy.
View Article and Find Full Text PDFLi-Fraumeni Syndrome: Imaging Features and Guidelines.
Radiographics
August 2024
From the Department of Radiology and Biomedical Imaging (B.G., I.D.d.O.S., A.N.R., A.S.B.), Section of Interventional Radiology (Y.W.), Yale School of Medicine, 333 Cedar Street, PO Box 208042, Rm TE-2, New Haven, CT 06520; Department of Radiology, Brigham and Women's Hospital, Boston, Mass (A. Keraliya); Magnus Hospital, Hyderabad, India (D.I.); Department of Radiology, Lahey Hospital and Medical Care Center, Burlington, Mass (R.T.); and Department of Radiology, Mayo University, Rochester, Minn (A. Khandelwal).
Li-Fraumeni syndrome (LFS) is a rare autosomal dominant familial cancer syndrome caused by germline mutations of the tumor protein p53 gene which encodes the p53 transcription factor, also known as the "guardian of the genome." The most common types of cancer found in families with LFS include sarcomas, leukemia, breast malignancies, brain tumors, and adrenocortical cancers. Osteosarcoma and rhabdomyosarcoma are the most common sarcomas.
View Article and Find Full Text PDFRecurrent Upper Gastrointestinal Bleeding due to Radiation-Induced Hemorrhagic Gastroduodenal Ectasia: A Review of Current Treatment Options for Radiation-Induced Gastric Injury.
Case Rep Gastroenterol
June 2024
Division of Gastroenterology and Hepatology, NYU Grossman School of Medicine, New York, NY, USA.
Introduction: Acute upper gastrointestinal bleeding is one of the most common medical emergencies that present to the hospital, and delineating the underlying etiology is essential to provide adequate definitive treatment. The purpose of this case report was to review the diagnosis and treatment of a rare complication known as radiation-induced hemorrhagic gastritis (RIHG) that can occur in patients with prior radiation exposure. The motivation for this study arose from the identification of a case within our institution.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!