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Hereditary angioedema in children: Review and practical perspective for clinical management.
Pediatr Allergy Immunol
December 2024
French National Reference Center for Angioedema (CREAK), Center of Excellence and Reference (ACARE), Internal Medicine Department, Grenoble Alpes University Hospital, Grenoble, France.
Background: Hereditary angioedema (HAE) in children has specific features and requires multidisciplinary management.
Methods: We performed a literature search and underwent in-depth discussions to provide practical tools for physicians.
Results: HAE is a rare, life-threatening genetic disorder.
Treat the Patient as a Whole, Not Just the Laboratory Findings: A Case of Contaminated Blood Cultures With Subsequent Iatrogenic Complications.
Cureus
October 2024
Neurological Surgery, Paul Kaloostian M.D. Inc., Pasadena, USA.
Sepsis is a serious condition involving life-threatening infection-driven immune response and organ dysfunction. In the emergency department (ED), patients at high risk for sepsis or those with suspected sepsis are managed with a standardized protocol which includes empiric broad-spectrum antibiotic therapy pending blood culture results and susceptibilities, if applicable. While the benefits generally outweigh the risks, this approach may lead to complications, including allergic reactions, gastrointestinal irritation, acute kidney injury, and even financial toxicity, particularly in cases of contaminated blood cultures.
View Article and Find Full Text PDFOphthalmic Formulations for the Treatment of Allergic Conjunctivitis and Their Effect on the Ocular Surface: A Review of Safety and Tolerability Assessments in Clinical Trials.
J Clin Med
November 2024
Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Spain.
Allergic conjunctivitis (AC) is the most common allergic eye disorder. Antiallergic eyedrops are the first line of pharmacological treatment. However, the application of antiallergic eyedrops can potentially alter tear homeostasis and affect the ocular surface, which may result in iatrogenic diseases such as dye eye disease (DED).
View Article and Find Full Text PDFSpontaneous cerebrospinal fluid rhinorrhoea: a case report and literature review.
J Med Case Rep
November 2024
Department of Ear-Nose-Throat, Government Medical College, Omandurar, Government Estate, Chennai, 600002, Tamilnadu, India.
Article Synopsis
- - Cerebrospinal fluid rhinorrhea is a rare condition where cerebrospinal fluid leaks from the brain into the nasal cavity, caused by factors like trauma or spontaneous events.
- - A case study involved a 40-year-old woman with watery nasal discharge and headaches; initial allergic rhinitis treatment failed, leading to a diagnosis of cerebrospinal fluid rhinorrhea confirmed through tests.
- - Timely diagnosis and treatment are critical to avoid serious complications like meningitis; a combination of conservative and surgical methods tailored to the cause is key for effective management.
Delayed drug hypersensitivity reactions: How p-i transforms pharmacology into immunology.
Allergol Int
January 2025
ADR-AC GmbH, Holligenstr. 91, 3008 Bern, Switzerland. Electronic address:
Article Synopsis
- - Delayed drug hypersensitivity reactions (dDHRs) are caused by interactions between drugs and immune receptors (HLA and TCR) that activate T-cells without typical allergic mechanisms, leading to T-cell activation and potential complications like eosinophilia.
- - These reactions differ from classical immune responses because they involve changes in immune receptor structures that mimic allo-like interactions, causing abnormal T-cell responses and inflammation without innate immune system involvement.
- - Understanding the pharmacological interaction (p-i) mechanism is crucial for developing preventive strategies and treatments for dDHRs, and it may provide insights into TCR signaling and broader immune responses.
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