A visible-light-promoted cascade cyclization of 3-ethynyl-[1,1'-biphenyl]-2-carbonitriles with unsaturated α-bromocarbonyls for the synthesis of tetrahydrobenzo[]cyclopenta[]acridines is described. Three C(sp)-C(sp) bonds, one C(sp)-N bond, and three cycles can be formed in a single reaction through the addition of a C-centered radical to the carbon-carbon triple bond and three radical cyclizations. This reaction features mild conditions, wide substrate scope, and high bond-forming efficiency.
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| http://dx.doi.org/10.1021/acs.orglett.3c02938 | DOI Listing |
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