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[Atelectasis caused by mucus stasis].
Ned Tijdschr Geneeskd
March 2025
Zaans Medisch Centrum, afd. Intensive Care, Zaandam.
A 58-year-old female presented at the emergency department with dyspnea. Laboratory and X-ray analyses showed eosinophilia and a partial atelectasis of the left lung, respectively. Bronchoscopy demonstrated mucus plugs.
View Article and Find Full Text PDFEnhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces.
Laryngoscope Investig Otolaryngol
April 2025
Department of Otolaryngology University of Iowa Hospitals and Clinics lowa City lowa USA.
Objective: To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular.
Methods: A zwitterionic hydrogel thin film was photografted onto medical rubber surfaces and compared against non-zwitterionic hydrogel thin films and untreated surfaces to determine its impact on mucus contact angles, mucus flow on sheets and tubes, and mucus plugging.
Results: Zwitterionic and conventional hydrogel films significantly reduce the mucus contact angles and the tilt required to initiate mucus flow on sheets and in tubular systems.
Successful treatment by switching from benralizumab to dupilumab in a patient with allergic bronchopulmonary mycosis caused by Schizophyllumcommune.
Respir Investig
March 2025
Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, 143-8541, Japan.
A 79-year-old female patient with a history of bronchial asthma was diagnosed with allergic bronchopulmonary aspergillosis. Her symptoms temporarily improved with inhaled corticosteroid/long-acting β2-agonist therapy. However, 10 months after treatment, her asthma symptoms worsened.
View Article and Find Full Text PDFRecent advances in asthma mucus biology and emerging treatment strategies.
Curr Opin Pulm Med
March 2025
Division of Respirology, Department of Medicine, St Joseph's Healthcare and McMaster University, Hamilton, Ontario, Canada.
Purpose Of Review: To describe the recent advances in the pathobiology and treatment of mucus hypersecretion in asthma, a critical factor contributing to airway obstruction, inflammation, and impaired lung function.
Recent Findings: Significant progress has been made in understanding how mucin protein regulation, mucus viscosity, and adhesion are affected by cytokine-driven inflammation, especially interleukin-13, and defects in ion transport mechanisms. Advances in imaging techniques, such as multidetector computed tomography (MDCT) and hyperpolarized gas MRI, allow for a more precise assessment of mucus plugging and associated ventilation defects.
Dupilumab Efficacy in Relation to Changes in Club Cell Secretory Protein 16.
Ann Allergy Asthma Immunol
March 2025
Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Background: Although the performance of dupilumab in severe asthma has been evaluated, the detailed mechanism underlying its effect remains unclear.
Objective: We analyzed the effect of dupilumab on serum club cell secretory protein 16 (CC16).
Methods: Twenty-five patients who were administered dupilumab and underwent computed tomography (CT) before and approximately 4 months after the introduction of dupilumab were included.
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