AI Article Synopsis
- A study evaluated the pharmacokinetics of Isavuconazole (ISA) in 13 lung transplant recipients, focusing on how well the drug penetrates lung tissue.
- The results showed mean serum concentrations of ISA at 2, 4, and 24 hours post-administration: 3.30, 5.12, and 6.31, respectively.
- Additionally, the drug reached effective levels in the epithelial lining fluid of the lungs, indicating it is safe and effective for use in this patient population.
Article Abstract
Isavuconazole's (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), and 6.31 (SD 0.95) at 2 h, 4 h, and 24 h respectively. Mean concentrations in the epithelial lining fluid were 0.969 (SD 0.895), 2.141 (SD 1.265), and 2.812 (SD 0.693) at the same time points. ISA is a drug with a tolerable safety profile that achieves adequate concentrations in the lung.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583689 | PMC |
| http://dx.doi.org/10.1128/aac.00613-23 | DOI Listing |
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