AI Article Synopsis
- Alterations in the intestinal environment are linked to various diseases, with FFAR4 playing a significant role in regulating hormone secretion and microbiota in the intestine.
- The study confirmed that intestinal FFAR4 influences glucagon-like peptide 1 secretion and its relationship with glucose utilization at a specific time (ZT12) in mice.
- A deficiency in intestinal FFAR4 was found to cause poor glucose tolerance in mice at ZT12, and supplementation improved glucose utilization, mirroring the dawn phenomenon observed in diabetic patients.
Article Abstract
Alterations in the intestinal environment are associated with various diseases, and FFAR4 is abundantly enriched in the intestine, where it has been shown to have the ability to regulate intestinal hormone secretion and intestinal microbiota; here, we confirmed previous reports. Meanwhile, we found that intestinal FFAR4 regulates glucagon-like peptide 1 secretion by decreasing abundance and show that such change is associated with the level of glucose utilization at ZT12 in mice. Intestinal FFAR4 deficiency leads to severely impaired glucose tolerance at the ZT12 moment in mice, and supplementation ameliorates the abnormal glucose utilization at the ZT12 moment caused by FFAR4 deficiency, which is very similar to the dawn phenomenon in diabetic patients. Collectively, our data suggest that intestinal deteriorates glucose tolerance at the daily light to dark transition by affecting .
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654094 | PMC |
| http://dx.doi.org/10.1128/msystems.00573-23 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!