Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4103/jcrt.jcrt_1742_21 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Self-Assembled Pt/Honokiol Nanomicelles for the Treatment of Sepsis-Associated Acute Kidney Injury.
ACS Biomater Sci Eng
December 2024
Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.
Sepsis is a severe and complex systemic infection that can result in multiple organ dysfunction. Sepsis-associated acute kidney injury (SAKI), caused by inflammatory response, oxidative stress, and cellular apoptosis, is a common complication that seriously impacts patient survival rates. Herein, a potent and novel metal-polyphenol nanomicelle can be efficiently self-assembled with Pt and honokiol (HK) by the chelation, π-π conjugation, hydrophobic action, and the surfactant properties of Tween-80.
View Article and Find Full Text PDFHonokiol ameliorates silica-induced lung fibrosis by inhibiting macrophage pyroptosis via modulating cGAS/STING signaling.
Int Immunopharmacol
December 2024
School of Public Health, Xinxiang Medical University, Xinxiang 453003, China; School of Public Health, North China University of Science and Technology, Tangshan 063000, China. Electronic address:
Silicosis is a life-threatening occupational disease because of inhaling silica dust, leading to chronic inflammation, pyroptosis, and fibrosis. Unfortunately, it is still lacking effective pharmacological intervention currently. Honokiol (HKL), a natural extract with biological activity from Magnolia bark, is known for its antioxidant and anti-inflammatory biological effects.
View Article and Find Full Text PDFReveal the potent antidepressant effects of Zhi-Zi-Hou-Pu Decoction based on integrated network pharmacology and DDI analysis by deep learning.
Heliyon
November 2024
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.
Article Synopsis
- Traditional Chinese medicine (TCM), particularly Zhi-Zi-Hou-Pu Decoction (ZZHPD), shows promise in treating depression, but its mechanisms have not been fully explored.
- The study employed network pharmacology and molecular docking to uncover pharmacological targets related to ZZHPD and its active compounds, finding significant interactions affecting inflammation and neuroimmune cell functions.
- Key findings include the identification of 18 active compounds, particularly honokiol and eriocitrin, along with implications for drug interactions that could affect treatment effectiveness and side effects in clinical settings.
Honokiol protects against diabetic retinal microvascular injury via sirtuin 3-mediated mitochondrial fusion.
Front Pharmacol
October 2024
Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China.
Article Synopsis
- Mitochondrial dysfunction and oxidative stress are crucial factors in diabetic retinal damage, and the study investigates the antioxidant Honokiol (HKL) for its potential protective effects against diabetic retinopathy (DR).
- Using a type 2 diabetic mouse model, HKL was found to reduce retinal vascular leakage and capillary cell apoptosis, enhancing cell viability and decreasing oxidative stress when exposed to high glucose levels.
- The protective effects of HKL were linked to the activation of sirtuin 3 (SIRT3), suggesting that HKL improves mitochondrial function and offers a potential new treatment approach for DR.
SIRT3 alleviates mitochondrial dysfunction and senescence in diabetes-associated periodontitis by deacetylating LRPPRC.
Free Radic Biol Med
November 2024
Department of Periodontology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China; State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Nanjing, China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China. Electronic address:
Diabetes-associated periodontitis (DP) is recognized as an inflammatory disease that can lead to teeth loss. Uncontrolled chronic low-grade inflammation-induced senescence impairs the stemness of human periodontal stem cells (hPDLSCs). Sirtuin 3 (SIRT3), an NAD-dependent deacetylase, is pivotal in various biological processes and is closely linked to aging and aging-related diseases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!