Pilomatrix carcinoma is a rare tumor arising from the hair follicle matrix cells most commonly seen in the head and neck region. Also known as "calcified epithelial carcinoma of Melherbe," it was first reported in 1980 by Lopansri and Mihm. Since then till date to the best of our knowledge only around 125 cases were reported in literature, of which only 11 cases were reported to arise from histologically proven areas of previous pilomatrixoma which is the benign variant. One such case is being reported here along with the review of literature. A 50-year-old man presented with a swelling in the nape of his neck since 6 months, which was gradually increasing in size. He had a history of similar swelling at the same site 18 months back for which he underwent a surgery at a center outside. Final histopathology report was suggestive of pilomatrixoma with negative margin. Wide local excision of the tumor with 3 cm margin, placement of surgical clips followed by a primary closure was done. The final histopathology report is suggestive of pilomatrix carcinoma. The patient has no recurrence in 6 months follow-up. The differential diagnosis of pilomatrix carcinoma should be considered in cases of recurrent skin tumors. Wide local excision is the preferred treatment. Re-excision should be done in margin positive cases and cases where simple excision was done due to improper preoperative diagnosis. Due to the rarity of the disease, adjuvant treatment is not properly defined.

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcrt.jcrt_720_21DOI Listing

Publication Analysis

Top Keywords

pilomatrix carcinoma
16
cases reported
8
final histopathology
8
histopathology report
8
report suggestive
8
wide local
8
local excision
8
carcinoma
5
cases
5
systematic review
4

Similar Publications

A 63-year-old man, with no past medical history, presented with an asymptomatic, progressively evolving polypoid lesion for 2 years in the left ciliary region. Physical examination revealed an exophytic tumor lesion of firm consistency and lobulated surface, with regular and well-defined borders. It measured 2 cm in diameter, and had a brownish-violet coloration with whitish areas (Figure 1).

View Article and Find Full Text PDF
Article Synopsis
  • Pilomatrix carcinoma (PMC) is a rare and aggressive hair follicle tumor with high recurrence and metastasis risks, often stemming from benign pilomatricoma or arising independently.
  • A study analyzed various surgical treatments for PMC by reviewing 257 articles from major databases, ultimately including 50 relevant studies, highlighting the effectiveness of different surgical methods.
  • The findings revealed that Mohs micrographic surgery (MMS) had no recurrences in 17 treated cases, while surgical excision resulted in a 34.5% recurrence rate, suggesting that MMS is a superior option to minimize recurrence and preserve tissue.
View Article and Find Full Text PDF
Article Synopsis
  • High-grade endometrioid carcinomas can exhibit a solid basaloid morphology with geographic necrosis (SB-GN), which is a key characteristic of a new tumor type called pilomatrix-like high-grade endometrioid carcinoma (PiMHEC).
  • A study screened 300 endometrial carcinomas for SB-GN, identifying four cases (1.3%) that demonstrated this pattern, all exhibiting aggressive behaviors despite some being mismatch repair (MMR) deficient.
  • One SB-GN case met most diagnostic criteria for PiMHEC, revealing notable genetic mutations but lacking the typical shadow cells; molecular analyses indicated novel variants, suggesting SB-GN may indicate poor prognosis and potential treatment implications.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!