AI Article Synopsis

  • Preeclampsia (PE) is linked to endothelial dysfunction and blood clotting issues, but the diagnostic potential of certain blood factors in predicting PE has not been studied in Ghana.
  • A case-control study involving 90 women with PE and 90 normotensive pregnant women assessed various blood coagulation parameters and natural anticoagulants through blood tests.
  • Findings revealed significant differences in coagulation markers, indicating most women with PE are in a hypercoagulable state, suggesting that factors like protein C, protein S, and antithrombin III might serve as effective diagnostic tools for PE and its subtypes.

Article Abstract

Preeclampsia (PE) is associated with endothelial injury and hemostatic abnormalities. However, the diagnostic role of coagulation parameters and natural anticoagulants in predicting PE has not been explored in Ghana. This study assessed plasma levels of these factors as surrogate markers of PE and its subtypes. This case-control study included 90 women with PE (cases) and 90 normotensive pregnant women (controls). Blood samples were drawn for the estimation of complete blood count and coagulation tests. The prothrombin time (PT), activated partial thromboplastin time (APTT), and the calculation of the international normalized ratio (INR) were determined by an ACL elite coagulometer while the levels of protein C (PC), protein S (PS), antithrombin III (ATIII), and D-dimers were also measured using the solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) method. All statistical analyses were performed using the R Language for Statistical Computing. Results showed significantly (< .05) shortened APTT (28.25 s) and higher D-dimer levels (1219.00 ng/mL) among PE women, as well as low levels of PC (1.02 µg/mL), PS (6.58 µg/mL), and ATIII (3.99 ng/mL). No significant difference was found in terms of PT and INR. From the receiver operating characteristic analysis, PC, PS, and ATIII could significantly predict PE and its subtypes at certain cutoffs with high accuracies (area under the curve [AUC] ≥0.70). Most women with PE are in a hypercoagulable state with lower natural anticoagulants. PC, PS, and ATIII are good predictive and diagnostic markers of PE and its subtypes (early-onset PE [EO-PE] and late-onset PE [LO-PE]) and should be explored in future studies.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548802PMC
http://dx.doi.org/10.1177/10760296231204604DOI Listing

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