Neonatal hypoxia-ischemia reduces nicotinamide adenine dinucleotide (NAD) and SIRT6 levels in the injured hippocampus.Hippocampal high mobility group box-1 (HMGB1) release is significantly increased after neonatal hypoxia-ischemia.Nicotinamide mononucleotide (NMN) treatment normalizes hippocampal NAD and SIRT6 levels, with significant decrease in caspase-3 activity and HMGB1 release.NMN improves early developmental behavior, as well as motor and memory function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548811 | PMC |
| http://dx.doi.org/10.1177/17590914231198983 | DOI Listing |
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