AI Article Synopsis
- The study examines the link between the interleukin-6 (IL-6) gene variant rs1800795 and IL-6 levels in Turkish COVID-19 patients, focusing on how these factors relate to clinical severity.
- It involved a cohort of 148 patients, measuring IL-6 concentrations and genotyping, categorizing patients as asymptomatic, symptomatic, or in intensive care.
- Results indicated that the GG genotype and G allele were more frequent in asymptomatic patients, while symptomatic and ICU patients had higher frequencies of the C allele, suggesting a connection between genotype and the severity of COVID-19 symptoms.*
Article Abstract
Background: disease 2019 (COVID-19) is a multisystem disease of global significance. Interleukin (IL)-6 is a soluble cytokine with a pleiotropic effect on inflammation and the immune response.
Objectives: Investigate the relationship between the interleukin ) rs1800795 variant and IL6 level in Turkish patients with COVID-19 disease.
Design: Prospective cohort study.
Setting: Tertiary care hospital.
Patients And Methods: Real-time polymerase chain reaction (RT-PCR)-positive and/or chest computerized tomography CT) scancompatible COVID-19 patients were enrolled in the study. The clinical data and whole blood samples were collected from April 1, 2020, to August 1, 2020. genotyping was performed by the PCR-restriction fragment-length polymorphism (RFLP) method in 148 patients. Serum IL-6 concentrations were measured using the ELISA method in 89 patients. We evaluated the patients in three groups: asymptomatic, symptomatic, and intensive care unit patients.
Main Outcome Measures: rs1800795 genotype frequencies and serum IL-6 levels in COVID-19 patients with different clinical presentations.
Sample Size: 148 cases.
Results: IL6 rs180079 GG genotype and G allele frequency increased in PCR positive patients compared to PCR-negative patients ( ˂ 0.000). rs1800795 GC genotype and C allele frequency were lower in PCR-positive patients than in PCR-negative patients. GG genotype and G allele frequency were higher in asymptomatic patients than in the symptomatic and intensive care unit groups. The IL6 C allele frequency was lower in asymptomatic patients than in the symptomatic and intensive care unit groups. rs1800795 GG genotype and G allele frequency were higher in CT negative patients than CT positive patients, while GC genotype and C allele frequency were higher in CT positive patients than negative patients. IL6 level elevation was seen in the asymptomatic patients compared to the symptomatic and intensive care unit groups.
Conclusions: These findings suggest that rs1800795 may contribute to the susceptibility of COVID-19 in people to Turkish origin.
Limitations: Further large-scale studies in different genetic populations are needed as this is a single-center, prospective study.
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| http://dx.doi.org/10.1080/15257770.2023.2263490 | DOI Listing |
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