AI Article Synopsis
- - Norepinephrine (NE) is a key neurotransmitter released from neurons in the locus coeruleus, playing a significant role in various physiological and pathological processes in the central nervous system.
- - Neuroinflammation is often seen in neurological diseases, and the activation of microglia (immune cells in the brain) is crucial to this process.
- - NE interacts with different types of adrenergic receptors on microglia, leading to changes in their activation and thereby influencing conditions like chronic pain, anxiety, and depression.
Article Abstract
Norepinephrine (NE) is an important neurotransmitter in the central nervous system. NE is released from locus coeruleus neurons and is involved in a variety of physiological and pathological processes. Neuroinflammation is a common manifestation of many kinds of neurological diseases. The activation of microglia directly affects the status of neuroinflammation. Several kinds of adrenergic receptors, which anchor on microglia and can be regulated by NE, affect the activation of microglia and neuroinflammation. NE influences chronic pain, anxiety, and depression by regulating the activation of microglia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528971 | PMC |
| http://dx.doi.org/10.1002/ibra.12001 | DOI Listing |
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