AI Article Synopsis

  • Overnight increases in arterial stiffness, measured by cardio-ankle vascular index (CAVI), were linked to sleep-disordered breathing in patients with acute heart failure.
  • Significant overnight changes in blood pressure and CAVI were observed in a study of 60 hospitalized patients, with CAVI rising from 8.4 to 9.1.
  • The majority of patients with increased CAVI (70%) were more likely to have moderate-to-severe sleep-disordered breathing, suggesting that respiratory issues may significantly contribute to increased arterial stiffness during hospitalization for heart failure.

Article Abstract

Overnight increases in arterial stiffness associated with sleep-disordered breathing may adversely affect patients with acute heart failure. Thus, we investigated overnight changes in arterial stiffness and their association with sleep-disordered breathing in patients hospitalized for acute heart failure. Consecutive patients with acute heart failure were enrolled. All participants underwent overnight full polysomnography following the initial improvement of acute signs and symptoms of acute heart failure. The arterial stiffness parameter, cardio-ankle vascular index (CAVI), was assessed before and after polysomnography. Overall, 60 patients (86.7% men) were analyzed. CAVI significantly increased overnight (from 8.4 ± 1.6 at night to 9.1 ± 1.7 in the morning, P < 0.001) in addition to systolic and diastolic blood pressure (from 114.1 mmHg to 121.6 mmHg, P < 0.001; and from 70.1 mmHg to 78.2 mmHg, P < 0.001, respectively). Overnight increase in CAVI (ΔCAVI ≥ 0) was observed in 42 patients (70%). The ΔCAVI ≥ 0 group was likely to have moderate-to-severe sleep-disordered breathing (i.e., apnea-hypopnea index ≥15, 55.6% vs 80.9%, P = 0.047) and greater obstructive respiratory events (29.4% vs 58.5%, P = 0.041). In multivariable analysis, moderate-to-severe sleep-disordered breathing and greater obstructive respiratory events were independently correlated with an overnight increase in CAVI (P = 0.033 and P = 0.042, respectively). In patients hospitalized for acute heart failure, arterial stiffness, as assessed by CAVI, significantly increased overnight. Moderate-to-severe sleep-disordered breathing and obstructive respiratory events may play an important role in the overnight increase in cardio-ankle vascular index.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41440-023-01448-yDOI Listing

Publication Analysis

Top Keywords

acute heart
20
heart failure
20
arterial stiffness
16
sleep-disordered breathing
12
patients acute
12
overnight changes
8
changes arterial
8
acute
6
overnight
5
patients
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!