Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis.

Weijie Wang Jinxuan Yang Pinfang Kang Jinsong Bai Xiaoli Feng Liuqi Huang Yiming Zhang Yuechun Wu Bi Tang Hongju Wang JianJie Jiang Minghua Li Bing Zhao Xinglou Yang

Virol Sin

Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China. Electronic address:

Published: December 2023

- The study created 3D cardiac organoids that have layers of heart cells (cardiomyocytes) and blood vessel cells (endothelial cells).
- Infection with SARS-CoV-2 is linked to various types of damage in the heart.
- It's important to focus on heart health in patients who have had COVID-19.

• Establishment of 3D cardiac organoids composed of cardiomyocyte and endothelial layers. • SARS-CoV-2 infection causes multi-lineage cardiac injuries. • Cardiovascular health should be greatly concerned in COVID-19 patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786654	PMC
http://dx.doi.org/10.1016/j.virs.2023.09.005	DOI Listing

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