AI Article Synopsis
- The study focuses on creating a new cross-coupling reaction using ruthenium as a catalyst to combine β-ketoamides with organoboronates.
- This reaction involves breaking the alkenyl C-N bond of a compound called β-enaminoamide, which is formed by reacting β-ketoamide with pyrrolidine.
- An amide directing group is essential in facilitating this reaction alongside the ruthenium catalyst.
Article Abstract
Herein, we report the development of ruthenium-catalysed cross-coupling reaction of β-ketoamides as alkenyl electrophiles with organoboronates. This reaction presumably proceeds the cleavage of the alkenyl C-N bond of the β-enaminoamide, which is generated from the β-ketoamide and pyrrolidine, and is promoted by a nearby amide directing group and a ruthenium catalyst.
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| http://dx.doi.org/10.1039/d3cc04265k | DOI Listing |
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Article Synopsis
- The study focuses on creating a new cross-coupling reaction using ruthenium as a catalyst to combine β-ketoamides with organoboronates.
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