AI Article Synopsis
- Researchers identified two new alkaloids, Eleganine A and Eleganine B, from the stems and leaves of a specific plant, along with 11 previously known compounds.
- The structural characteristics and configurations of the new compounds were determined using advanced techniques like UV, IR, HR-ESI-MS, NMR, and electronic circular dichroism.
- All isolated compounds were tested for anti-inflammatory effects and their ability to inhibit glucose-induced mesangial cell proliferation, but none demonstrated significant activity at concentrations below 50 μM.
Article Abstract
Two new monoterpene indole alkaloids, Eleganine A () and Eleganine B (), along with 11 known compounds (3-13) were isolated from the stems and leaves of . Compound 1 is a gelsenicine-related monoterpenoid indole alkaloid possessing an iridoid unit. Their structures and absolute configurations of - were established by UV, IR, HR-ESI-MS, NMR spectroscopy, and electronic circular dichroism data analyses. All isolated compounds were evaluated for their anti-inflammatory and inhibiting glucose-induced mesanginal cell proliferation activities. None of them showed activity with IC far beyond 50 M.
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| http://dx.doi.org/10.1080/14786419.2023.2261070 | DOI Listing |
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